[Protective effects of cyproheptadine on calcium paradox in isolated rat hearts].

Author: ShenH J, XinH B, ZhangB H

Paper Details 
Original Abstract of the Article :
The protective effects of cyproheptadine, an antiserotonin-antihistaminic agent with calcium channel blocker activity, on calcium paradox in isolated Langendorff's heart in rats were studied. After a 5 min of calcium-free perfusion [standard Krebs-Henseleit (K-H) buffer without calcium, gassed with ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/1300023

データ提供:米国国立医学図書館(NLM)

Cyproheptadine's Protective Effects Against Calcium Paradox in Isolated Rat Hearts

The calcium paradox, a phenomenon that can occur in isolated hearts, presents a fascinating challenge in the desert of cardiovascular research. This study, like a scientific expedition venturing into a harsh desert environment, explores the potential protective effects of cyproheptadine, a drug known for its calcium channel blocker activity. The researchers, like intrepid explorers seeking solutions in a challenging environment, investigated the effects of cyproheptadine on myocardial injury induced by calcium paradox in isolated rat hearts.

Cyproheptadine: A Protective Oasis

The research revealed that cyproheptadine effectively protected the heart from the damaging effects of calcium paradox, demonstrating its ability to reduce myocardial injury and protect against the loss of mechanical activity. This protective effect, like a refreshing oasis in a parched desert, suggests that cyproheptadine could have potential therapeutic implications for cardiovascular conditions. The researchers concluded that cyproheptadine's protective effects may be related to its actions of blocking calcium channels, protecting anti-oxygen free radical enzymes, and scavenging oxygen free radicals in myocardial tissues.

Hope for the Future of Cardiovascular Research

This study, like a beacon of hope shining in the desert of cardiovascular research, offers valuable insights into the potential therapeutic benefits of cyproheptadine. The researchers, like skilled desert navigators, have uncovered a potential oasis in the desert of calcium paradox, opening up new possibilities for protecting the heart from damage. This research paves the way for further investigation into the role of calcium channel blockers in mitigating cardiovascular injury.

Dr.Camel's Conclusion

The desert of cardiovascular research is vast and complex, but this study, like a camel caravan venturing into uncharted territory, offers valuable insights into the protective effects of cyproheptadine against calcium paradox. The researchers, like experienced desert guides, have uncovered a potential solution to a challenging problem, suggesting that cyproheptadine might play a valuable role in protecting the heart from damage. This research inspires continued exploration of the desert of cardiovascular research, seeking new solutions and improving patient outcomes.

Date :
  1. Date Completed 1993-05-14
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

1300023

DOI: Digital Object Identifier

1300023

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PICO Info
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Languages

Chinese

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