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Neuroleptic-induced changes in the anxiolytic and myorelaxant properties of diazepam in the rat.

Author: FillmoreM T, RugglesJ L, TaukulisH K

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Chlorpromazine and haloperidol enhanced the anxiolytic effect of diazepam in rats, while thioridazine and pimozide did not. Both chlorpromazine and haloperidol reduced diazepam's muscle relaxation effect.
Paper Details　
Original Abstract of the Article :
Diazepam (2.0 mg/kg) was injected (IP) into rats 30 min before chlorpromazine (2.5, 5.0, or 10.0 mg/kg) on ten occasions. All doses of chlorpromazine enhanced the capacity of diazepam to increase rats' exploration of the exposed arms of an elevated plus-maze, an animal screening test for anxiolytic ...See full text at original site
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引用元：
https://doi.org/10.1016/0091-3057(92)90052-h

データ提供：米国国立医学図書館（NLM）

Neuroleptics and Diazepam: A Complex Interaction

Diazepam, a benzodiazepine commonly used for anxiety and muscle relaxation, can interact with other medications, including neuroleptics. This study investigated the effects of various neuroleptics on the anxiolytic and myorelaxant properties of diazepam in rats.

Unraveling the Interaction

The study found that some neuroleptics, such as chlorpromazine and haloperidol, enhanced diazepam's anxiolytic effects but reduced its myorelaxant effects. This complex interaction highlights the need for careful consideration when prescribing diazepam in combination with neuroleptics.

Navigating the Complexities of Medication Interactions

This research underscores the importance of understanding medication interactions to ensure optimal patient care. Just as a camel navigates the unpredictable desert environment, healthcare providers need to be aware of the potential consequences of drug interactions to ensure safe and effective treatment.

Dr.Camel's Conclusion

This study reveals the complex interplay between diazepam and certain neuroleptics, highlighting the importance of careful monitoring and consideration when prescribing these medications together. The findings emphasize the need for ongoing research to fully understand and manage these interactions.

Date :
  1. Date Completed 1992-04-02
  2. Date Revised 2019-07-12
Further Info :

Pubmed ID

1347171

DOI: Digital Object Identifier

10.1016/0091-3057(92)90052-h

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・Side Effects of pimozide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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