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A randomized prospective study to compare cefotetan with cefuroxime plus metronidazole as prophylaxis in elective colorectal surgery.

Author: KarranS J, SkipperD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cefotetan, a single-agent antibiotic, was as effective as the combination of cefuroxime and metronidazole in preventing wound infections after elective colorectal surgery. Cefotetan is safe and effective, with a broad spectrum of activity and a long half-life.
Paper Details　
Original Abstract of the Article :
This study compares the efficacy of cefotetan with the combination of cefuroxime plus metronidazole as antibiotic prophylaxis in elective colorectal surgery when given over the first 24 h postoperatively. There was no significant difference in wound infection rates between the two groups (14.7% for ...See full text at original site
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引用元：
https://doi.org/10.1016/0195-6701(92)90155-f

データ提供：米国国立医学図書館（NLM）

Comparing Antibiotic Prophylaxis for Elective Colorectal Surgery

The field of [surgical oncology] is constantly seeking to optimize [antibiotic prophylaxis] strategies for [elective colorectal surgery], aiming to minimize [postoperative infection] rates. This study compares the efficacy of [cefotetan] and a combination of [cefuroxime plus metronidazole] as [antibiotic prophylaxis] in [elective colorectal surgery]. The study analyzes [wound infection rates] and other [infective complications] in patients receiving either [cefotetan] or [cefuroxime plus metronidazole].

Cefotetan Effective as Single-Agent Prophylaxis for Elective Colorectal Surgery

The study found no significant difference in [wound infection rates] between the two groups, indicating that both [cefotetan] and [cefuroxime plus metronidazole] are effective in preventing [postoperative infections]. This finding suggests that [cefotetan] may be a viable single-agent option for [prophylaxis] in [elective colorectal surgery], offering a simpler and potentially more convenient treatment approach. The study also noted that both treatments were well-tolerated, with no significant [adverse reactions].

Choosing the Best Antibiotic Prophylaxis: A Collaborative Approach

This research provides valuable information for clinicians seeking to optimize [antibiotic prophylaxis] strategies for [elective colorectal surgery]. Like finding the right path through a desert, selecting the best antibiotic prophylaxis requires careful consideration of individual patient factors, including [surgical procedure], [patient risk factors], and [allergies]. A collaborative approach between surgeon and physician is essential to ensure optimal patient outcomes.

Dr.Camel's Conclusion

This study demonstrates the effectiveness of cefotetan as a single-agent antibiotic prophylaxis for elective colorectal surgery, offering a convenient alternative to combination therapies. It’s like choosing the right camel for a desert journey – some camels are better suited for certain conditions than others. Finding the best option requires careful consideration and collaboration.

Date :
  1. Date Completed 1992-07-23
  2. Date Revised 2019-08-27
Further Info :

Pubmed ID

1351498

DOI: Digital Object Identifier

10.1016/0195-6701(92)90155-f

Related Literature

Article Analysis
・Side Effects of cefuroxime
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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