The future of 5-HT1A receptor agonists. (Aryl-piperazine derivatives).

Author: MiuraS, MurasakiM

Paper Details 
Original Abstract of the Article :
At present the dominant position among anti-anxiety medications has changed from meprobamate to the benzodiazepine derivatives. In order to avoid benzodiazepine's (BZ) undesirable side effects such as impairment of psycho-motor function, memory impairment, low dose dependence and withdrawal symptoms...See full text at original site
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引用元:
https://doi.org/10.1016/0278-5846(92)90103-l

データ提供:米国国立医学図書館(NLM)

Beyond Benzodiazepines: The Rise of Serotonin Normalizers

The field of [anxiety treatment] has been on a quest for [more effective and safe medications]. This review examines [the potential of aryl-piperazine derivatives, such as buspirone, as a new generation of anxiolytics]. The authors highlight [the advantages of these compounds in terms of reduced side effects compared to benzodiazepines]. A notable finding is [that these derivatives work as 5-HT1A receptor partial agonists, potentially offering a more balanced approach to anxiety management].

A Different Approach to Anxiety Relief

This research suggests [that aryl-piperazine derivatives may offer a viable alternative to benzodiazepines for treating anxiety]. The study highlights [their potential for reducing anxiety without the sedative and muscle relaxant effects of benzodiazepines]. The authors emphasize the need for [further research to optimize their effectiveness and explore their potential for treating depression].

Finding a Balanced Path to Calmness

This review offers [a promising new direction in the search for effective anxiety treatments]. Just as a camel seeks a steady path through the desert, patients may find [a more balanced and sustainable path to calmness with these new agents]. This research encourages [continued exploration of serotonin normalizers as a potential alternative to benzodiazepines, with a focus on improving their efficacy and safety].

Dr.Camel's Conclusion

The quest for anxiety relief continues, and this review introduces a new generation of anxiolytics, the aryl-piperazine derivatives. Like a desert oasis offering a respite from the harsh environment, these compounds may provide a gentler and more balanced approach to managing anxiety, potentially offering a pathway to calmer and more fulfilling lives. Further research is needed to fully explore their potential and ensure their safety and efficacy.

Date :
  1. Date Completed 1992-09-30
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

1355301

DOI: Digital Object Identifier

10.1016/0278-5846(92)90103-l

Related Literature

SNS
PICO Info
in preparation
Languages

English

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