Paper Details 
Original Abstract of the Article :
Riluzole, a new compound with anticonvulsant properties, was found to induce a dose-dependent decrease in the uptake of 3H-dopamine, 3H-GABA and 3H-glutamate into striatal synaptosomes when added to the incubation medium or after in vivo administration, whereas an inhibition of 3H-choline uptake was...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1111/j.1472-8206.1992.tb00109.x

データ提供:米国国立医学図書館(NLM)

Riluzole: A Potential Oasis in the Desert of Neurological Disorders

Neurological disorders like Parkinson's disease are often associated with complex changes in neurochemical activity in the brain. This study investigates the effects of riluzole, a medication used to treat amyotrophic lateral sclerosis (ALS), on neurochemical markers in the striatum, a brain region involved in movement control. The researchers examined the impact of riluzole on the uptake of various neurotransmitters, including dopamine, GABA, glutamate, and acetylcholine, in the striatum of rats. They found that riluzole significantly affected the uptake of these neurotransmitters, suggesting that riluzole may have broader implications for neurological disorders beyond ALS.

Riluzole's Impact on Neurochemical Activity: A Potential for Broader Applications

The study's findings suggest that riluzole's effects extend beyond ALS, potentially influencing neurochemical activity in other neurological disorders. The study's observations on neurotransmitter uptake provide valuable insights into the potential applications of riluzole for treating various neurological conditions.

Navigating Neurological Disorders: A Guide for Patients

If you are diagnosed with a neurological disorder, it's important to discuss all available treatment options with your neurologist. Riluzole may be a valuable addition to your treatment plan, especially if you are struggling with conditions like Parkinson's disease or ALS.

Dr. Camel's Conclusion

Neurological disorders can feel like an endless desert, filled with complex and often debilitating symptoms. This study highlights the potential of riluzole to offer a refreshing oasis, potentially influencing neurochemical activity and improving outcomes for patients with a range of neurological conditions. It's a reminder that understanding the intricacies of the brain and its neurotransmitters can lead to new and innovative approaches for managing neurological disorders.

Date :
  1. Date Completed 1992-12-08
  2. Date Revised 2019-10-21
Further Info :

Pubmed ID

1385285

DOI: Digital Object Identifier

10.1111/j.1472-8206.1992.tb00109.x

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.