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Cardiovascular and pulmonary effects of atropine reversal of oxymorphone-induced bradycardia in dogs.

Author: CoplandV S, HaskinsS C, PatzJ D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Oxymorphone-induced bradycardia in dogs was effectively reversed by atropine. Atropine significantly increased heart rate, cardiac output, and other cardiovascular parameters.
Paper Details　
Original Abstract of the Article :
Oxymorphone was administered intravenously (IV) to 10 dogs (0.4 mg/kg initial dose followed by 0.2 mg/kg three times at 20-minute intervals). Four hours after the last dose of oxymorphone, heart rates were less than 60 bpm in six dogs. After atropine (0.01 mg/kg IV) was administered, heart rate decr...See full text at original site
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引用元：
https://doi.org/10.1111/j.1532-950x.1992.tb01719.x

データ提供：米国国立医学図書館（NLM）

Atropine: A Lifesaver in the Desert of Opioid-Induced Bradycardia

Opioids can be a valuable tool for managing pain, but they can also have significant side effects, such as bradycardia, or a slow heart rate. This research investigates the use of atropine to reverse oxymorphone-induced bradycardia in dogs.

A Timely Intervention

The study found that atropine effectively reversed oxymorphone-induced bradycardia in dogs, restoring heart rate and improving cardiovascular parameters. This is like finding a hidden oasis in the desert, providing a life-saving intervention to counter the potentially dangerous effects of opioid-induced bradycardia. This research highlights the importance of having a plan to manage potential complications associated with opioid use.

A Crucial Tool for Safety

This research underscores the importance of understanding the potential risks and benefits of opioid medications. It also highlights the importance of having appropriate interventions, such as atropine, available to manage potential complications. This is like having a trusty camel and a compass to navigate the potentially treacherous landscape of opioid use.

Dr.Camel's Conclusion

This research demonstrates the crucial role of atropine in reversing opioid-induced bradycardia. By understanding the potential for this complication and having the necessary interventions available, we can ensure the safety and well-being of patients receiving opioid medication.

Date :
  1. Date Completed 1992-11-17
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

1413473

DOI: Digital Object Identifier

10.1111/j.1532-950x.1992.tb01719.x

Related Literature

Article Analysis
・Effects of oxymorphone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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