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[Anti-emetic effect and safety of ondansetron tablet in double-blind comparison with placebo].

Author: AkasakaY, AriyoshiY, FurueH, IkedaM, NiitaniH, OhtaJ, OtaK, SuminagaM, TaguchiT, TsukagoshiS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Ondansetron tablets were found to be effective in preventing nausea and vomiting associated with high-dose cisplatin chemotherapy. In a double-blind, placebo-controlled study, 58.1% of patients receiving ondansetron had good anti-emetic effects, compared to only 16.7% of patients receiving placebo.
Paper Details　
Original Abstract of the Article :
Ondansetron, a selective 5-HT3 receptor antagonist, has already been reported to have a marked effect to alleviate or prevent nausea and vomiting associated with cancer chemotherapy, after its intravenous administration. The present study was planned to examine the usefulness of its tablet form, whi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1417014

データ提供：米国国立医学図書館（NLM）

The Anti-Emetic Effect of Ondansetron Tablets

This study delves into the realm of anti-emetic therapy, exploring the effectiveness of ondansetron tablets in combating nausea and vomiting associated with chemotherapy. Just like a camel navigating a vast desert, researchers sought to find a reliable solution for this common side effect. This study used a double-blind design, which is like covering your eyes and nose with a scarf while walking across the desert to ensure that the results are not skewed by any preconceived ideas.

The researchers investigated the anti-emetic effect of ondansetron tablets compared to a placebo in patients receiving cisplatin chemotherapy. They found that ondansetron tablets were significantly more effective in reducing nausea and vomiting compared to the placebo. Ondansetron tablets, like a cool oasis in the heat of the desert, provided a soothing respite from the discomfort of chemotherapy.

Ondansetron Tablets: A Promising Anti-Emetic

The study revealed that ondansetron tablets were significantly superior to placebo in reducing nausea and vomiting in patients receiving cisplatin chemotherapy. The efficacy rate for ondansetron was 58.1%, compared to only 16.7% for the placebo group. The study also observed a significant difference in the number of patients requiring rescue medication with ondansetron injection. Interestingly, the number of patients requiring rescue medication was much higher in the placebo group (31 cases) compared to the ondansetron group (12 cases).

A Glimpse into Nausea and Vomiting Relief

This research provides a valuable insight into the effectiveness of ondansetron tablets in managing chemotherapy-induced nausea and vomiting. As a camel traversing the desert, you wouldn't want to be caught unprepared for a sandstorm, and similarly, patients undergoing chemotherapy can benefit from a reliable anti-emetic like ondansetron to help navigate the side effects. The study suggests that ondansetron tablets are a safe and effective treatment option for patients undergoing cisplatin chemotherapy.

Dr.Camel's Conclusion

Just as a camel relies on its humps to store water in the arid desert, ondansetron tablets serve as a valuable resource for patients undergoing chemotherapy, offering relief from the unpleasant side effects of nausea and vomiting. This study highlights the importance of exploring innovative treatment strategies in the field of oncology.

Date :
  1. Date Completed 1992-11-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1417014

DOI: Digital Object Identifier

1417014

SNS
PICO Info
in preparation
Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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