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A randomized, double-blind, double-dummy, parallel-group, multicenter, dose-reduction trial of the minimal effective doses of budesonide and fluticasone dry-powder inhalers in adults with mild to moderate asthma.
Author: GreefhorstLouis A P M, JoubertJames R, KunaPiotr, MagnussenHelgo
Original Abstract of the Article :
BACKGROUND: Inhaled corticosteroids are established first-line anti-inflammatory treatment for asthma. Clinical trials comparing inhaled corticosteroids must take into consideration that because of their excellent effect at low doses, they typically induce a near-maximal response in asthma patients....See full text at original site
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引用元:
https://doi.org/10.1016/s0149-2918(03)80212-6
データ提供:米国国立医学図書館(NLM)
Exploring the Minimal Effective Doses of Budesonide and Fluticasone for Asthma
The vast landscape of [asthma treatment] is constantly evolving, with researchers seeking to optimize existing therapies. This study, like a determined caravan traversing a sandy expanse, focused on determining the minimal effective doses (MEDs) of two widely used inhaled corticosteroids, [budesonide] and [fluticasone propionate], in adults with mild to moderate asthma.
The researchers employed a meticulous [dose-reduction trial] approach, allowing them to pinpoint the lowest doses that effectively control asthma symptoms. Their findings, like a well-charted path across the desert, reveal that the MEDs for both medications were remarkably similar. This suggests that the effectiveness of these medications might be independent of the specific dose within a certain range.
The Importance of Finding the Optimal Dose for Effective Asthma Management
The study's findings are significant for asthma management. They highlight the potential for [adjusting the dose of inhaled corticosteroids] to find the most effective treatment while minimizing potential side effects. This approach, like a wise camel selecting the optimal path across the dunes, prioritizes both effectiveness and safety.
Optimizing Asthma Treatment for Long-Term Well-being
This research reminds us that, like the shifting sands of the desert, individual needs and responses to medications may vary. Patients should work closely with their healthcare providers to find the most effective and safe dose for their specific condition. This collaborative approach, like a shared journey across the dunes, fosters a path towards long-term well-being and optimal asthma control.
Dr.Camel's Conclusion
This research is a significant contribution to our understanding of the optimal dosing of inhaled corticosteroids in asthma management. The study's findings offer guidance for finding the most effective doses while minimizing potential side effects, ultimately contributing to improved patient outcomes.
Date :
- Date Completed 2004-01-08
- Date Revised 2019-09-22
Further Info :
Related Literature
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