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Differential region-specific regulation of central alpha 1-adrenoceptor binding following chronic haloperidol and clozapine administration in the rat.

Author: CahirMarie, KingDavid J, MawhinneyTim

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of chronic haloperidol and clozapine treatment on alpha(1)-adrenoceptor characteristics in different rat brain regions. The study found that both haloperidol and clozapine increased alpha(1)-adrenoceptor density in the thalamus, which may contribute to the antipsychotic activity and/or alpha(1)-adrenoceptor centrally mediated side effects of both drugs. Clozapine also selectively upregulated cortical alpha(1)-adrenoceptor density, which may contribute to its atypical properties.
Paper Details　
Original Abstract of the Article :
RATIONALE: Many antipsychotics exhibit potent anti-alpha(1)-adrenergic receptor activity, which has been suggested to contribute to typical and atypical antipsychotic effects and to the production of centrally mediated side effects. OBJECTIVES: To assess the relative contribution of alpha(1)-adreno...See full text at original site
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引用元：
https://doi.org/10.1007/s00213-003-1639-z

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2004-06-28
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

14534772

DOI: Digital Object Identifier

10.1007/s00213-003-1639-z

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English

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