Effects of statins on platelet inhibition by a high loading dose of clopidogrel.

Author: BestaFelicitas, GawazMeinrad, LiZhongyan, MassbergSteffen, MüllerIris, SchulzChristian

Paper Details 
Original Abstract of the Article :
BACKGROUND: Recent studies suggested that some HMG-CoA reductase blockers might inhibit the antiplatelet activity of clopidogrel. Therefore, we analyzed how various statins together with a high loading dose of clopidogrel (600 mg) affect platelet aggregation. METHODS AND RESULTS: Seventy-seven pati...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/14568892

データ提供:米国国立医学図書館(NLM)

Statins and Clopidogrel: Investigating Potential Interactions

Statins, medications used to lower cholesterol, and clopidogrel, an antiplatelet drug used to prevent blood clots, are commonly prescribed for cardiovascular disease. This study investigates the potential interactions between statins and clopidogrel, like analyzing the effects of different desert plants on a traveler's journey.

No Significant Interaction Found Between Statins and Clopidogrel

The study found that the use of statins did not significantly affect the antiplatelet activity of clopidogrel, like finding that different desert plants do not interfere with the traveler's water supply. This observation provides reassurance for clinicians who prescribe both statins and clopidogrel, like knowing that a particular desert plant is safe to consume.

Implications for Cardiovascular Disease Management

This study provides valuable information about the safety and effectiveness of combining statins and clopidogrel, like mapping out a safe and reliable route through a diverse desert landscape.

Dr. Camel's Conclusion

This research is important for understanding the potential interactions between commonly prescribed medications. It reinforces the importance of careful consideration of drug interactions, but also offers reassurance about the safety of combining statins and clopidogrel. Just as a traveler must be aware of the potential hazards of the desert, healthcare professionals must remain vigilant in evaluating drug interactions to ensure the well-being of their patients.

Date :
  1. Date Completed 2003-11-20
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

14568892

DOI: Digital Object Identifier

01.CIR.0000099507.32936.C0

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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