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Old wine in new bottles: reviving old therapies for alopecia areata using rodent models.

Author: LuiHarvey, ShapiroJerry, SundbergJohn P, TangLiren

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Alopecia areata is a hair loss condition caused by an autoimmune reaction. This review discusses the use of immunomodulating therapies, including contact sensitizers and immunomodulators, to treat alopecia areata. The authors highlight the successful use of anthralin and mechlorethamine in animal models of alopecia areata.
Paper Details　
Original Abstract of the Article :
Alopecia areata is regarded as a tissue-restricted autoimmune disease of hair follicles in which follicular activity is arrested because of the continued activity of lymphocytic infiltrates. Actual loss of hair follicles does not occur, even in hairless lesions. A variety of immunomodulating therapi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14582676

データ提供：米国国立医学図書館（NLM）

Reviving Old Therapies for Alopecia Areata

This study explores the potential of repurposing existing therapies for the treatment of alopecia areata, a tissue-restricted autoimmune disease affecting hair follicles. The authors highlight the limited effectiveness of current treatment options, emphasizing the need for new therapeutic approaches. They present a compelling case for utilizing rodent models to evaluate the efficacy of existing drugs, such as mechlorethamine and anthralin, which have shown promising results in treating alopecia areata in animal studies. The researchers suggest that these therapies, previously used for other conditions, might offer valuable insights into the underlying cellular and molecular mechanisms of alopecia areata, paving the way for future drug development.

Repurposing Old Therapies for Alopecia Areata

The study proposes a novel approach to treating alopecia areata by revisiting existing therapies that have demonstrated efficacy in animal models. This approach can be compared to finding a hidden treasure in the sands of time - re-examining old treatments with new perspectives. The researchers suggest that repurposing existing drugs for alopecia areata could offer a faster and more cost-effective route to developing new therapies.

A Camel's Perspective on Alopecia Areata Treatment

As a camel, I know the desert can be unforgiving. Losing your hair is like losing your protective coat in the harsh sun. It's important to explore all avenues for treatment, including revisiting old therapies with a fresh perspective. This study presents a promising approach to addressing alopecia areata by repurposing existing drugs. It's like finding a hidden spring in the desert - a source of relief and hope.

Dr.Camel's Conclusion

Repurposing existing therapies for alopecia areata, particularly mechlorethamine and anthralin, holds promise for effective treatment. Further research using rodent models is needed to validate their efficacy and safety.
Date :
  1. Date Completed 2004-06-02
  2. Date Revised 2016-10-21
Further Info :

Pubmed ID

14582676

DOI: Digital Object Identifier

S0022-202X(15)52969-2

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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