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Reduction in distractibility with AF102B and THA in the macaque.

Author: CrawfordK Casey, FisherAbraham, FittenL Jaime, HalgrenEric, O'NeillJoseph, SiembiedaDouglas W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Cholinomimetics, such as the m-1 muscarinic agonist civemeline and the cholinesterase inhibitor tacrine, may reduce distractibility in primates. Both drugs significantly increased accuracy and decreased reaction time in a visuospatial attention task in bonnet macaque monkeys.
Paper Details　
Original Abstract of the Article :
Distractibility in primates may be influenced by central cholinergic systems. Two cholinomimetics, the m-1 muscarinic agonist (+/-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine (AF102B, civemeline) and the cholinesterase inhibitor tetrahydroaminoacridine (THA, tacrine), were compared to vehi...See full text at original site
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引用元：
https://doi.org/10.1016/j.pbb.2003.08.006

データ提供：米国国立医学図書館（NLM）

Distractibility in Primates: Exploring the Role of Cholinergic Systems

The brain is a complex and fascinating organ, and scientists are constantly seeking to unravel its mysteries. This research delves into the intricate world of attention and distractibility in primates, focusing on the role of cholinergic systems. The study investigated the effects of two cholinomimetics, AF102B and THA, on distractibility in macaque monkeys using an automated visuospatial attention task. The researchers found that both drugs significantly improved task accuracy, suggesting their potential to reduce distractibility. This research, like a detailed map of a desert landscape, provides valuable insights into the neural mechanisms of attention and distractibility.

A Journey to Enhanced Focus: Unveiling the Power of Cholinomimetics

The study's findings suggest that muscarinic agonists and cholinesterase inhibitors may play a role in modulating attention and reducing distractibility. This discovery could have implications for developing new therapies for conditions involving attentional deficits. This is like discovering a hidden oasis of focus in the midst of a distracting desert, providing a pathway to improved cognitive function.

Potential for Therapeutic Applications: Navigating the Sands of Attention

The study's findings open up exciting possibilities for exploring the therapeutic potential of cholinomimetics in treating disorders involving attentional difficulties. This research, like a compass guiding us through a challenging desert, offers hope for developing new strategies to enhance attention and focus.

Dr. Camel's Conclusion

This research sheds light on the role of cholinergic systems in modulating attention and distractibility in primates. The study's findings suggest that cholinomimetics may hold potential as therapeutic agents for treating disorders involving attentional deficits. This is a desert journey that reveals new possibilities for improving cognitive function.
Date :
  1. Date Completed 2004-06-18
  2. Date Revised 2019-07-12
Further Info :

Pubmed ID

14592682

DOI: Digital Object Identifier

10.1016/j.pbb.2003.08.006

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in preparation
Languages

English

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