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Effect on high-density lipoprotein cholesterol of maximum dose simvastatin and atorvastatin in patients with hypercholesterolemia: results of the Comparative HDL Efficacy and Safety Study (CHESS).

Author: BallantyneChristie M, BlazingMichael A, DavidsonMichael H, DeLuccaPaul, HunninghakeDonald B, HustadCarolyn M, PalmisanoJoanne, RamseyKaren E, YuanZhong

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Simvastatin (80 mg) increased HDL-C and apo A-I significantly more than did atorvastatin (80 mg) in patients with hypercholesterolemia, regardless of HDL-C level at baseline or the presence of the metabolic syndrome.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Previous studies have shown that effects on high-density lipoprotein cholesterol (HDL-C) may differ among statins. METHODS: A multicenter, randomized, double-blind, parallel-dose study was conducted in 917 hypercholesterolemic patients to compare the efficacy of 80 mg/d simvastatin vers...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14597936

データ提供：米国国立医学図書館（NLM）

HDL Cholesterol: A Desert Oasis of Good Health

High-density lipoprotein cholesterol (HDL-C) is a vital component of cardiovascular health, often referred to as "good" cholesterol. It's like a precious oasis in the vast desert of our cardiovascular system, helping to clear out harmful cholesterol. This research delves into the effects of two popular statins, simvastatin and atorvastatin, on HDL-C levels in patients with hypercholesterolemia. The researchers are like explorers searching for the best route to enhance HDL-C levels, comparing these two statins to see which one provides the most beneficial effect.

Simvastatin: A Winning Formula for HDL-C

The research reveals a clear winner: simvastatin. It significantly increased HDL-C levels compared to atorvastatin, like a skilled desert guide leading travelers to a plentiful oasis. This finding suggests that simvastatin might be a more effective option for patients seeking to raise their HDL-C levels.

A Journey to Better Cardiovascular Health

This research underscores the importance of finding the right approach to manage cholesterol levels. Just as a desert traveler needs to choose the right path to reach a life-giving oasis, patients with hypercholesterolemia need to work with their doctor to find the best strategy to improve their cardiovascular health. This study provides valuable insight into the potential benefits of simvastatin, offering a potentially better route to a healthier heart.

Dr. Camel's Conclusion

This research provides a valuable roadmap for navigating the complex desert of cholesterol management. Simvastatin emerged as a potential oasis in this study, offering hope for patients seeking to improve their HDL-C levels. This research reminds us that the journey to better cardiovascular health requires careful planning and personalized strategies, just like navigating a desert requires a skilled guide.

Date :
  1. Date Completed 2004-02-25
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

14597936

DOI: Digital Object Identifier

S000287030300440X

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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