Paper Details

  1. Home
  2. Paper Details

Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.

Author: DunnerDavid L, HeimChristine M, KeitnerGabor, KellerMartin B, KleinDaniel N, KornsteinSusan, McCulloughJames P, NemeroffCharles B, NinanPhilip T, RothbaumBarbara O, RushA John, SchatzbergAlan F, ThaseMichael E, WeissPaul M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study examined the effectiveness of different treatments for chronic depression in 681 patients. Combining antidepressants and psychotherapy was the most effective treatment. However, for patients with a history of early childhood trauma, psychotherapy alone was as effective as antidepressants, and the combination therapy was only slightly better. This suggests that psychotherapy may be especially important for treating chronic depression in individuals with a history of childhood trauma.
Paper Details　
Original Abstract of the Article :
Major depressive disorder is associated with considerable morbidity, disability, and risk for suicide. Treatments for depression most commonly include antidepressants, psychotherapy, or the combination. Little is known about predictors of treatment response for depression. In this study, 681 patient...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC283585/

データ提供：米国国立医学図書館（NLM）

Healing the Scars of Childhood Trauma

Major depressive disorder is a debilitating condition, and finding effective treatments is a priority for mental health professionals. This study investigates the effectiveness of psychotherapy, pharmacotherapy, and their combination in treating patients with chronic forms of major depression, particularly those with a history of childhood trauma. The researchers examined the unique needs of patients with chronic depression and the potential benefits of different treatment approaches. This is like a meticulous excavation of the psychological landscape, exploring the complex interplay between depression and trauma.

The study found that psychotherapy alone was superior to antidepressant monotherapy in patients with a history of childhood trauma. This suggests that for individuals who have experienced early adversity, addressing the emotional and psychological impacts of trauma may be crucial for effective depression treatment. This is like discovering that a specific type of plant thrives only in a certain type of desert environment – the right treatment needs to be tailored to the specific needs of the individual.

The Power of Psychotherapy

This study underscores the importance of psychotherapy in treating chronic forms of depression, particularly in individuals with a history of childhood trauma. It's like discovering a hidden well of healing within the desert – psychotherapy can provide a source of strength and resilience for those who have been through difficult experiences.

A Holistic Approach to Healing

This research highlights the need for a holistic approach to mental health treatment, considering the individual's history and unique needs. It's like appreciating the interconnectedness of the desert ecosystem – we must consider all factors that influence an individual's well-being.

Dr. Camel's Conclusion

This study reminds us that healing from the scars of childhood trauma is a complex journey, often requiring a multi-faceted approach. Just like a camel navigating a desert, we must consider all the factors that influence an individual's recovery, including the power of psychotherapy.

Date :
  1. Date Completed 2004-02-02
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

14615578

DOI: Digital Object Identifier

PMC283585

Related Literature

Article Analysis
・Effective treatment of depression
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.