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Kinetics of inhibition of glutamate uptake by antioestrogens.

Author: MäenpääHanna, SaransaariPirjo, TähtiHanna

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tamoxifen and toremifene, antioestrogens used for breast cancer treatment, have been reported to cause retinal changes. The study investigated the mechanism by which these drugs inhibit glutamate uptake in retinal pigment epithelial cells. Both drugs were found to competitively inhibit glutamate transport, potentially hampering glutamate homeostasis in the retina.
Paper Details　
Original Abstract of the Article :
The antioestrogens, tamoxifen and its more recent homologue toremifene, are used in the therapy of breast cancer. Tamoxifen has been reported to cause retinal changes as side effects. Both compounds inhibited glutamate uptake in retinal pigment epithelial cells, and the present study was conducted t...See full text at original site
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引用元：
https://doi.org/10.1034/j.1600-0773.2003.930404.x

データ提供：米国国立医学図書館（NLM）

Antiestrogens and Glutamate Uptake: A Delicate Balance in the Desert of Vision

This study explores the potential effects of antiestrogens, commonly used in breast cancer treatment, on glutamate uptake in retinal pigment epithelial cells, highlighting the importance of understanding the potential side effects of these medications. It's like exploring a vast desert landscape of ocular health, searching for hidden pathways that may be affected by these medications.

Antiestrogens and Glutamate Transport: A Crossroads in the Desert of Vision

The study reveals that antiestrogens, like tamoxifen and toremifene, can inhibit glutamate uptake in retinal pigment epithelial cells, potentially affecting retinal function. It's like discovering a hidden oasis in the desert, where the delicate balance of glutamate transport is disrupted by these medications.

A Reminder to Watch Our Vision: Navigating the Desert of Side Effects

The findings of this study underscore the importance of monitoring visual function in patients receiving antiestrogen therapy, emphasizing the potential for these medications to affect retinal health. It's like a camel navigating the desert, keeping a watchful eye on the horizon for potential dangers and side effects.

Dr. Camel's Conclusion

This study provides a compelling case for carefully monitoring visual function in patients receiving antiestrogen therapy. It's like a guidepost in the desert of vision, reminding us to be aware of the potential side effects of these medications and take necessary precautions to protect our ocular health.
Date :
  1. Date Completed 2004-05-20
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

14629741

DOI: Digital Object Identifier

10.1034/j.1600-0773.2003.930404.x

Related Literature

Article Analysis
・Side Effects of toremifene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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