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Prevalence and treatment of decreased bone density in renal transplant recipients: a randomized prospective trial of calcitriol versus alendronate.

Author: JefferyJohn R, KarpinskiMartin E, LeslieWilliam D, NickersonPeter W, RushDavid N

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Alendronate and calcitriol, both with calcium supplementation, resulted in significant increases in bone mineral density in long-term renal transplant recipients with reduced bone mineral density. Alendronate may be more effective at the spine, but further studies are needed to confirm this and to determine long-term benefits and effects on fracture rates.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Reduced bone mineral density (BMD) is common in long-term renal transplant recipients and results in a high incidence of fractures. The optimal therapy for these patients is not known. METHODS: Baseline BMD determinations were obtained in 211 long-term adult renal transplant recipients....See full text at original site
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引用元：
https://doi.org/10.1097/01.TP.0000092523.30277.13

データ提供：米国国立医学図書館（NLM）

Bone Density in Renal Transplant Recipients: A Comparative Trial of Calcitriol and Alendronate

The field of [transplant medicine] is constantly striving to improve the long-term health of [transplant recipients]. This research focuses on a common challenge faced by [renal transplant recipients], [reduced bone mineral density (BMD)]. The authors conducted a [randomized prospective trial] to compare the effectiveness of two treatments, [calcitriol] and [alendronate], in preventing [bone loss] in this population.

Boosting Bone Health: Effective Treatments for Renal Transplant Recipients

The study demonstrates that both [calcitriol] and [alendronate], when combined with [calcium supplementation], effectively increased [BMD] in [renal transplant recipients] over a one-year period. While [alendronate] showed a trend towards greater effectiveness at the [spine], further research is needed to confirm this finding and to evaluate the long-term benefits of these treatments.

Maintaining Bone Health: A Priority for Transplant Recipients

This research underscores the importance of addressing [bone health] in [renal transplant recipients]. The findings suggest that [calcitriol] and [alendronate] can play a significant role in preventing [bone loss] and reducing the risk of [fractures] in this population. This is a reminder that maintaining [bone health] is essential for overall well-being, particularly for individuals who have undergone [organ transplantation].

Dr.Camel's Conclusion

Just as a camel relies on its strong bones to navigate the rugged desert terrain, [renal transplant recipients] need to maintain strong bones to live fulfilling lives. This research provides valuable insights into the effectiveness of [calcitriol] and [alendronate] in preventing [bone loss] in this population. It's a reminder that the journey of recovery after [transplantation] requires ongoing attention to all aspects of health, including [bone health].

Date :
  1. Date Completed 2004-01-21
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

14657693

DOI: Digital Object Identifier

10.1097/01.TP.0000092523.30277.13

Related Literature

Article Analysis
・Effective treatment of bone density
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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