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Effects of high ticlopidine doses on platelet function in acute coronary syndrome patients.

Author: BélangerPatrick, DiodatiJean G, PalisaitisDonald A, PharandChantal

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated whether a higher dose of ticlopidine would lead to a faster inhibition of platelet activation and aggregation in patients with acute coronary syndromes. The study found that 500 mg twice daily of ticlopidine resulted in significantly greater reduction in platelet activation and aggregation compared to 250 mg twice daily, especially after 2 days of treatment.
Paper Details　
Original Abstract of the Article :
BACKGROUND: We investigated whether higher doses of ticlopidine combined with acetylsalicylic acid would allow a faster inhibition of platelet activation and aggregation in patients with acute coronary syndromes potentially undergoing percutaneous coronary intervention with stent placement. METHODS...See full text at original site
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引用元：
https://doi.org/10.1097/00005344-200401000-00019

データ提供：米国国立医学図書館（NLM）

Optimizing Ticlopidine Dosage for Platelet Inhibition

[Platelet activation and aggregation] play a key role in [acute coronary syndromes]. This study investigates the impact of different [ticlopidine doses] on platelet function in patients undergoing [percutaneous coronary intervention (PCI)]. The authors compared the [effectiveness] of 250 mg and 500 mg doses of ticlopidine combined with acetylsalicylic acid. They discovered that [higher doses of ticlopidine lead to faster and more significant inhibition of platelet activation and aggregation].

Higher Ticlopidine Doses Improve Platelet Inhibition

The study found that a higher dose of ticlopidine (500 mg twice daily) produced significantly greater inhibition of platelet activation and aggregation compared to a lower dose (250 mg twice daily). This finding suggests that a higher dose may be more effective in preventing platelet-related complications during PCI.

Personalized Approaches to Platelet Inhibition

Just as a camel adapts to the harsh desert environment, we can adapt treatment strategies to individual patient needs. This study highlights the importance of considering dosage adjustments based on patient characteristics and the specific medical procedure. Tailoring treatment plans to optimize platelet inhibition could lead to better outcomes for patients with acute coronary syndromes.

Dr.Camel's Conclusion

Like a camel traversing a vast and unpredictable desert, the journey of treating acute coronary syndromes requires adaptability. This study shows that a higher dose of ticlopidine can be more effective in preventing platelet complications. It reminds us that personalized approaches to medicine are crucial for navigating the complex landscape of patient care.

Date :
  1. Date Completed 2004-04-13
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

14668578

DOI: Digital Object Identifier

10.1097/00005344-200401000-00019

Related Literature

Article Analysis
・Effects of ticlopidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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