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Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats.

Author: CerdáM, CortijoJ, Llombart-BoschA, Martinez-LosaM, MataM, MorcilloE J, RuízA, SantangeloF, Serrano-MollarA

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Oxidative stress plays a role in pulmonary fibrosis, suggesting that antioxidants could be beneficial. This study investigated the effect of N-acetylcysteine (NAC) on bleomycin-induced lung damage, mucus secretory cells hyperplasia, and mucin Muc5ac gene expression in rats. NAC significantly reduced collagen deposition, fibrotic area, and inflammatory markers in bleomycin-exposed rats. Additionally, it effectively decreased mucus secretory cells hyperplasia and Muc5ac expression. These findings suggest that NAC might offer therapeutic potential in treating pulmonary fibrosis by mitigating oxidative stress and reducing mucus hypersecretion.
Paper Details　
Original Abstract of the Article :
Oxidative stress is involved in the pathogenesis of pulmonary fibrosis, therefore antioxidants may be of therapeutic value. Clinical work indicates that N-acetylcysteine (NAC) may be beneficial in this disease. The activity of this antioxidant was examined on bleomycin-induced lung damage, mucus sec...See full text at original site
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引用元：
https://doi.org/10.1183/09031936.03.00018003

データ提供：米国国立医学図書館（NLM）

N-acetylcysteine: A Potential Oasis for Bleomycin-Induced Lung Damage

Pulmonary fibrosis, a debilitating lung disease, is a complex and challenging condition to manage. This research investigates the potential therapeutic benefits of N-acetylcysteine (NAC) for bleomycin-induced lung damage in rats. The authors demonstrate that oral NAC reduces collagen deposition, lessens the fibrotic area, and decreases lung tumor necrosis factor-alpha and myeloperoxidase activity. Notably, NAC also reduces the number of mucus secretory cells in the airway epithelium and decreases Muc5ac gene expression. These findings suggest that NAC may offer a promising therapeutic avenue for addressing bleomycin-induced lung damage, potentially mitigating the progression of this debilitating condition.

A Glimmer of Hope for Pulmonary Fibrosis

This study offers encouraging findings regarding the potential of NAC as a therapeutic agent for bleomycin-induced lung damage. The research suggests that NAC may hold promise as a valuable tool for mitigating the progression of this debilitating condition. The authors' findings provide a foundation for further investigation into the potential of NAC for treating pulmonary fibrosis in human patients.

Navigating the Desert of Pulmonary Fibrosis

This research underscores the importance of seeking out new and effective treatment options for pulmonary fibrosis. The study highlights the potential of NAC as a valuable tool for managing this challenging condition, offering a glimmer of hope for those navigating the desert of pulmonary fibrosis.

Dr.Camel's Conclusion

This research offers a ray of hope in the ongoing battle against pulmonary fibrosis. The study's findings suggest that NAC may hold promise as a therapeutic agent for addressing bleomycin-induced lung damage. The research serves as a reminder that even in the face of complex and challenging conditions, there is always hope for new and innovative solutions.

Date :
  1. Date Completed 2004-04-14
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

14680076

DOI: Digital Object Identifier

10.1183/09031936.03.00018003

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Article Analysis
・Effects of acetylcysteine oral inhalation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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