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Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trial.
Author: BattersonJ Robert, GilbertDonald L, SalleeFloyd R, SethuramanGopalan
Original Abstract of the Article :
OBJECTIVE: To compare the tic suppression, electrocardiogram (ECG) changes, weight gain, and side effect profiles of pimozide versus risperidone in children and adolescents with tic disorders. METHOD: This was a randomized, double-blind, crossover (evaluable patient analysis) study. Nineteen childr...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/14726728
データ提供:米国国立医学図書館(NLM)
Tic Reduction: Comparing Risperidone and Pimozide in Children with Tic Disorders
Tic disorders, such as Tourette's syndrome, can significantly impact the lives of children and adolescents. This study compares the effectiveness of risperidone and pimozide in reducing tic severity, while also evaluating their effects on electrocardiogram (ECG) changes, weight gain, and side effects. The authors conducted a randomized, double-blind, crossover study involving children and adolescents with tic disorders. The study findings reveal that risperidone was more effective in reducing tic severity than pimozide, but was associated with greater weight gain. Neither medication produced significant ECG changes.
Risperidone: A Potential Advantage for Tic Reduction
The study results suggest that risperidone might offer a potential advantage over pimozide in reducing tic severity. However, the greater weight gain associated with risperidone raises concerns and highlights the need for careful monitoring of patients receiving this medication. The study's findings provide valuable insights for healthcare providers in choosing the most appropriate treatment for tic disorders, considering both efficacy and potential side effects.
Navigating the Desert of Tic Disorders: Finding the Right Path to Relief
The study underscores the complexity of treating tic disorders, particularly in children and adolescents. Choosing the most effective and safe medication requires careful consideration of individual patient needs and potential risks. It's like navigating a vast desert, weighing the benefits of different oases against the potential dangers of each route. This research provides valuable information to guide healthcare providers in selecting the best treatment path for their young patients.
Dr. Camel's Conclusion
The study provides valuable insights into the comparative efficacy of risperidone and pimozide in reducing tic severity. While risperidone demonstrates potential superiority in tic suppression, its association with greater weight gain necessitates careful monitoring of patients. The study emphasizes the importance of individualizing treatment decisions for tic disorders, considering both efficacy and potential side effects. This research contributes to our understanding of tic disorders and guides us in finding the most effective and safe treatment strategies for young patients.
Date :
- Date Completed 2004-03-08
- Date Revised 2021-04-02
Further Info :
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