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Influence of glucose concentration on the effects of aspirin, ticlopidine and clopidogrel on platelet function and platelet-subendothelium interaction.
Author: ArrebolaMaría Monsalud, De La CruzJosé Pedro, González-CorreaJosé Antonio, GuerreroAna, PinachoAraceli, Sánchez de la CuestaFelipe, VillalobosMaría Auxiliadora
Original Abstract of the Article :
Clinical studies have shown that the ability of aspirin to prevent cerebrovascular accidents is weaker in patients with diabetes. The aim of this study was to determine whether high concentrations of glucose modified the effect of aspirin, ticlopidine and clopigodrel on platelet function and platele...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.ejphar.2003.10.055
データ提供:米国国立医学図書館(NLM)
Glucose and Aspirin: Exploring the Shifting Sands of Platelet Function
The world of blood clotting, like a vast desert, is a complex and delicate balance. Aspirin, like a well-placed oasis, is a commonly used medication to prevent blood clots, but its effectiveness can be influenced by factors such as high glucose levels, like a changing desert landscape. This study, like a research expedition into this challenging terrain, investigates the impact of high glucose concentrations on the antiplatelet effects of aspirin.
The researchers, like skilled desert explorers, found that high glucose levels, like a sandstorm in the desert, can diminish the effectiveness of aspirin in inhibiting platelet aggregation and nitric oxide production. However, their findings also show that the antiplatelet effects of ticlopidine and clopidogrel, like a reliable water source in the desert, are not significantly affected by high glucose levels.
This study, like a map guiding travelers through a complex desert, provides valuable insights into the interplay between glucose levels and platelet function, highlighting the importance of personalized approaches to antiplatelet therapy.
Navigating the Desert of Platelet Function: A Personalized Approach
The study findings, like a refreshing oasis in the desert, emphasize the importance of considering individual factors when managing platelet function and choosing antiplatelet therapy. It highlights the need for a tailored approach that takes into account factors such as glucose levels and the individual patient's needs.
Understanding the Shifting Sands of Blood Clotting: A Call for Vigilance
This study, like a beacon in the desert, reminds us that the field of blood clotting is constantly evolving. The researchers' findings underscore the importance of continued research and clinical vigilance to optimize antiplatelet therapy and ensure the safety and efficacy of these medications. This study serves as a reminder that the desert of blood clotting is a complex terrain that requires ongoing exploration and understanding to ensure patient well-being.
Dr.Camel's Conclusion
This study, like a caravan traversing a vast desert, brings us closer to understanding the intricate interplay between glucose levels and platelet function. The researchers, like skilled explorers, have uncovered valuable insights into the impact of high glucose on the effectiveness of aspirin, reminding us that a personalized approach to antiplatelet therapy is crucial. As we continue our journey through the desert of cardiovascular health, this study serves as a reminder of the importance of staying informed, adapting to new knowledge, and seeking the best possible care to ensure optimal patient outcomes.
Date :
- Date Completed 2004-09-21
- Date Revised 2019-06-24
Further Info :
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