Influence of glucose concentration on the effects of aspirin, ticlopidine and clopidogrel on platelet function and platelet-subendothelium interaction.

Author: ArrebolaMaría Monsalud, De La CruzJosé Pedro, González-CorreaJosé Antonio, GuerreroAna, PinachoAraceli, Sánchez de la CuestaFelipe, VillalobosMaría Auxiliadora

Paper Details 
Original Abstract of the Article :
Clinical studies have shown that the ability of aspirin to prevent cerebrovascular accidents is weaker in patients with diabetes. The aim of this study was to determine whether high concentrations of glucose modified the effect of aspirin, ticlopidine and clopigodrel on platelet function and platele...See full text at original site
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引用元:
https://doi.org/10.1016/j.ejphar.2003.10.055

データ提供:米国国立医学図書館(NLM)

Glucose and Aspirin: Exploring the Shifting Sands of Platelet Function

The world of blood clotting, like a vast desert, is a complex and delicate balance. Aspirin, like a well-placed oasis, is a commonly used medication to prevent blood clots, but its effectiveness can be influenced by factors such as high glucose levels, like a changing desert landscape. This study, like a research expedition into this challenging terrain, investigates the impact of high glucose concentrations on the antiplatelet effects of aspirin.

The researchers, like skilled desert explorers, found that high glucose levels, like a sandstorm in the desert, can diminish the effectiveness of aspirin in inhibiting platelet aggregation and nitric oxide production. However, their findings also show that the antiplatelet effects of ticlopidine and clopidogrel, like a reliable water source in the desert, are not significantly affected by high glucose levels.

This study, like a map guiding travelers through a complex desert, provides valuable insights into the interplay between glucose levels and platelet function, highlighting the importance of personalized approaches to antiplatelet therapy.

Navigating the Desert of Platelet Function: A Personalized Approach

The study findings, like a refreshing oasis in the desert, emphasize the importance of considering individual factors when managing platelet function and choosing antiplatelet therapy. It highlights the need for a tailored approach that takes into account factors such as glucose levels and the individual patient's needs.

Understanding the Shifting Sands of Blood Clotting: A Call for Vigilance

This study, like a beacon in the desert, reminds us that the field of blood clotting is constantly evolving. The researchers' findings underscore the importance of continued research and clinical vigilance to optimize antiplatelet therapy and ensure the safety and efficacy of these medications. This study serves as a reminder that the desert of blood clotting is a complex terrain that requires ongoing exploration and understanding to ensure patient well-being.

Dr.Camel's Conclusion

This study, like a caravan traversing a vast desert, brings us closer to understanding the intricate interplay between glucose levels and platelet function. The researchers, like skilled explorers, have uncovered valuable insights into the impact of high glucose on the effectiveness of aspirin, reminding us that a personalized approach to antiplatelet therapy is crucial. As we continue our journey through the desert of cardiovascular health, this study serves as a reminder of the importance of staying informed, adapting to new knowledge, and seeking the best possible care to ensure optimal patient outcomes.

Date :
  1. Date Completed 2004-09-21
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

14729378

DOI: Digital Object Identifier

10.1016/j.ejphar.2003.10.055

Related Literature

SNS
PICO Info
in preparation
Languages

English

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