Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.

Author: Giovanardi-RossiPaola, ParmeggianiAntonia, PosarAnnio, SangiorgiSimonetta

Paper Details 
Original Abstract of the Article :
We describe the case of a 10-year-old girl with two epileptic seizures and subcontinuous spike-waves during sleep, who presented unusual side-effects related to clobazam (CLB) monotherapy. High plasma levels of N-desmethyl-clobazam (N-CLB), the major metabolite of CLB were detected. The patient and ...See full text at original site
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引用元:
https://doi.org/10.1016/s0387-7604(03)00074-3

データ提供:米国国立医学図書館(NLM)

Unlocking the Mysteries of Clobazam: A Case of Unusual Side Effects

The world of medications is a complex and nuanced one, with each drug presenting a unique profile of potential side effects. This research, like a skilled pharmacologist investigating the intricate mechanisms of drug metabolism, explores a case of unusual side effects related to clobazam (CLB), a commonly prescribed anti-epileptic drug. The authors, like meticulous detectives piecing together the clues of a medical mystery, investigate the case of a 10-year-old girl experiencing unusual side effects while on CLB monotherapy, focusing on the role of genetic factors in drug metabolism.

The Importance of Genetic Testing: Unraveling Individualized Drug Responses

The case report's findings, like a treasure map leading to a hidden trove of knowledge, reveal the potential significance of genetic testing in understanding individualized drug responses. The authors, like scientists analyzing a complex biological experiment, carefully examine the patient's drug levels and genetic profile, uncovering a potential link between the patient's CYP2C19 genotype and the unusual side effects she experienced. This discovery, like a hidden oasis in the desert, highlights the importance of personalized medicine and the need to consider genetic factors in prescribing medications.

Guiding Treatment Strategies: Tailoring Medications to Individual Needs

This case report, like a compass guiding us through the complex landscape of drug interactions, underscores the importance of considering genetic factors in prescribing medications. The findings, like a roadmap revealing personalized paths to optimal treatment, emphasize the need to tailor drug therapy to the individual patient's genetic profile. This knowledge, like a precious resource discovered in the desert, allows us to navigate the complexities of drug metabolism and optimize treatment strategies, ensuring that patients receive the most effective and safest care possible.

Dr. Camel's Conclusion

This case report highlights the potential significance of genetic testing in understanding individualized drug responses, particularly in cases involving unusual side effects. The research, like a desert explorer uncovering a hidden oasis, provides valuable insights into the complex interplay between genetics and drug metabolism, emphasizing the importance of personalized medicine in optimizing treatment strategies.

Date :
  1. Date Completed 2004-04-15
  2. Date Revised 2019-09-11
Further Info :

Pubmed ID

14729419

DOI: Digital Object Identifier

10.1016/s0387-7604(03)00074-3

Related Literature

SNS
PICO Info
in preparation
Languages

English

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