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Clomipramine, clonazepam, and clonidine treatment of obsessive-compulsive disorder.

Author: AgrasW S, HewlettW A, VinogradovS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Clomipramine and clonazepam were effective in reducing obsessive-compulsive disorder (OCD) symptoms compared to diphenhydramine, a control medication. Clonazepam was particularly effective in the first 3 weeks of treatment. Clonidine was ineffective.
Paper Details　
Original Abstract of the Article :
Serotonergic reuptake inhibitors have been the primary medications for treatment of obsessive-compulsive disorder (OCD); however, other serotonergic and alpha 2-adrenergic medications also have been reported to reduce obsessive-compulsive symptoms. In this study, we compare three medications with re...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1474179

データ提供：米国国立医学図書館（NLM）

Investigating Treatment Options for Obsessive-Compulsive Disorder

The world of mental health is a vast desert, with researchers constantly seeking new oases of understanding and treatment for conditions like obsessive-compulsive disorder (OCD). This study delves into the treatment landscape for OCD, focusing on comparing the efficacy of three potential medications against a control medication, diphenhydramine. The study employed a randomized, double-blind, multiple crossover design, allowing researchers to meticulously compare the effects of clomipramine, clonazepam, and clonidine against diphenhydramine. The findings revealed promising results for both clomipramine and clonazepam in reducing OCD symptoms, highlighting their potential as valuable treatment options.

Clonazepam Shows Promise as an Alternative Treatment

Interestingly, the study discovered a significant cross-response between clomipramine and clonazepam, meaning that some patients who didn't respond well to one medication might experience significant improvement with the other. This suggests that clonazepam could serve as a valuable alternative treatment for individuals who don't find relief with clomipramine. Moreover, the researchers observed that clonazepam's effectiveness was evident early in treatment, and was not related to changes in anxiety levels.

Exploring the Implications for OCD Treatment

This research sheds light on the potential of clonazepam as a promising treatment option for OCD. It's important to remember that OCD is a complex condition, and finding the right treatment often involves a journey of trial and error. If you or a loved one is struggling with OCD, it's crucial to consult a mental health professional to discuss potential treatment options and develop a personalized care plan.

Dr.Camel's Conclusion

This study reminds us that the desert of mental health is full of hidden gems! Clonazepam emerges as a promising new oasis for those struggling with OCD, offering hope for effective treatment. It's important to remember that each individual's journey is unique, and finding the right treatment might involve exploring different options. Just like a camel traversing the desert, we must be persistent and patient in our search for solutions!

Date :
  1. Date Completed 1993-02-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1474179

DOI: Digital Object Identifier

1474179

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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