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[Effect of antenatal action of Thio-Tepa on spermatogenesis of mature 101/N and CBA mice].

Author: Khil'kevichL V, KuriloL F, Lil'pI G, ZhubinskaiaV P

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Thiophosphamide, an anti-cancer drug, was found to significantly reduce the number of spermatogonia A, preleptotene and pachytene spermatocytes, and spermatids in the testes of 101/H mice, suggesting potential reproductive toxicity.
Paper Details　
Original Abstract of the Article :
On pregnancy day 12 101/H and CBA mice were injected intraperitoneally 2.5 mg/kg bw thiophosphamide. 3.5-month-old male offspring were sacrificed. The drug effect on the testes was evaluated by karyologic analysis of the germ cell generations on stage 7 of the seminiferous epithelium cycle. A reliab...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1477370

データ提供：米国国立医学図書館（NLM）

The Impact of Thio-Tepa on Spermatogenesis: A Look at Mice

The study delves into the effects of thiophosphamide, a chemotherapy drug, on the reproductive system of mice. Like a traveler in the vast desert, the researchers meticulously examined the effects of thiophosphamide on the testes, specifically the germ cells responsible for sperm production. The study found that thiophosphamide caused a reduction in the number of spermatogonia, preleptotene and pachytene spermatocytes, and spermatids in 101/H mice. These findings suggest that thiophosphamide can have a significant impact on spermatogenesis, potentially leading to fertility issues.

Interplay of Species and Spermatogenesis

The study highlights the interspecies differences in the intensity of spermatogenesis and the recovery of germ cells after exposure to thiophosphamide. These findings underscore the complexity of reproductive processes and the need for further research to fully understand the impact of chemotherapy on fertility.

Navigating the Desert of Fertility and Chemotherapy

It's crucial for individuals undergoing chemotherapy to discuss potential reproductive impacts with their doctor. This includes understanding the potential for fertility issues and exploring options for preserving fertility.

Dr.Camel's Conclusion

This study emphasizes the potential impact of chemotherapy on fertility, underscoring the need for careful consideration of reproductive health during cancer treatment. Further research is essential to develop strategies for mitigating these effects and supporting patients' reproductive well-being.

Date :
  1. Date Completed 1993-02-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1477370

DOI: Digital Object Identifier

1477370

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Languages

Russian

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