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Treatment acceleration in radiotherapy: the relative time factors and dose-response slopes for tumours and normal tissues.

Author: HendryJ H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

A direct analysis of data from over 4500 patients with head and neck cancer confirmed the presence of a significant time factor in treatment effectiveness, with longer treatment times leading to better local control. The dose-response curve was characterized by a specific dose, and the effective doubling time for tumor clonogens was longer than expected. Care should be taken when accelerating treatments to improve local control, as late-reacting normal tissues have steeper dose-response curves and are more susceptible to long-term complications.
Paper Details　
Original Abstract of the Article :
A published collation of data for control of head and neck cancer in over 4500 patients has been subjected to direct analysis to deduce dose-response, fractionation, and time parameters. The analysis confirms the presence of a significant time factor of the order of 0.5-0.6 Gy/day, deduced previousl...See full text at original site
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引用元：
https://doi.org/10.1016/0167-8140(92)90252-p

データ提供：米国国立医学図書館（NLM）

Accelerating Cancer Treatment: Time is of the Essence

In the fight against cancer, time is of the essence. This study investigates the impact of treatment acceleration on the effectiveness of radiotherapy for head and neck cancer. The researchers analyzed data from over 4500 patients, examining the relationship between treatment time, dose-response, and tumor control. They found that while treatment acceleration can improve local control, it's crucial to carefully consider the potential impact on late-reacting normal tissues, which are more sensitive to rapid dose delivery. The study underscores the importance of balancing the benefits of treatment acceleration with the need to protect normal tissues from excessive radiation damage.

Optimizing Radiotherapy: A Balancing Act

The study highlights the complexities of optimizing radiotherapy treatment schedules, emphasizing the delicate balance between maximizing tumor control and minimizing damage to healthy tissues. The researchers' findings provide valuable insights into the impact of treatment acceleration, encouraging careful consideration of the dose-response relationships for both tumors and normal tissues.

Navigating the Landscape of Cancer Treatment

Cancer treatment is a journey that demands careful planning and execution. This study emphasizes the importance of considering the time factor in radiotherapy, balancing the need for effective treatment with the need to protect healthy tissues. The researchers' findings underscore the importance of tailoring treatment approaches to individual patients, taking into account their specific tumor characteristics and overall health status.

Dr. Camel's Conclusion

This study delves into the intricate world of radiotherapy treatment, highlighting the importance of considering the time factor in optimizing treatment schedules. The researchers' findings emphasize the need to carefully balance the benefits of treatment acceleration with the potential risks to normal tissues. Just as a camel adapts to the harsh desert environment, cancer patients must navigate their treatment journey with careful consideration of the complex factors at play. The study underscores the importance of personalized treatment approaches and ongoing research to refine radiotherapy protocols and improve outcomes for cancer patients.
Date :
  1. Date Completed 1993-02-11
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

1480778

DOI: Digital Object Identifier

10.1016/0167-8140(92)90252-p

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Article Analysis
・Effective treatment of head and neck cancer
SNS
PICO Info
in preparation
Languages

English

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