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The Utrecht experience with different treatment strategies in early rheumatoid arthritis.

Author: , BijlsmaJ W, JacobsJ W, VerstappenS M

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated different approaches to treating early rheumatoid arthritis (RA). Early treatment with disease-modifying antirheumatic drugs (DMARDs) showed initial benefits compared to a delayed approach, but these advantages were not sustained after 5 years. Among the early DMARD strategies, starting with methotrexate (MTX) or injectable gold resulted in better outcomes after two years, although more patients discontinued gold treatment compared to MTX. The study recommends that methotrexate is the preferred initial DMARD, with treatment tailored to individual patients.
Paper Details　
Original Abstract of the Article :
Since 1990 the Utrecht Rheumatoid Arthritis Cohort study group has performed several clinical trials on different treatment strategies in early rheumatoid arthritis (RA) patients. From 1990 till 1994, patients were randomly assigned to the pyramid strategy group or the early DMARD group. Patients in...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14969070

データ提供：米国国立医学図書館（NLM）

Early Rheumatoid Arthritis: A Journey Through the Desert of Disease

The desert of rheumatoid arthritis (RA) can be a challenging landscape, where early intervention is crucial for mitigating the disease's impact. This study investigates the effectiveness of different treatment strategies in patients with early RA, comparing the outcomes of delayed versus early treatment with disease-modifying antirheumatic drugs (DMARDs). This research is like a camel caravan, traversing the desert of RA, seeking to find the most effective oasis of treatment to protect travelers from the disease's ravages.

The Power of Early Intervention: A Wellspring of Knowledge

The study reveals that early introduction of DMARDs in patients with early RA leads to significant improvements in clinical outcomes compared to delayed treatment. This is like discovering a wellspring of knowledge in the desert of RA, highlighting the importance of timely intervention. The research also emphasizes the importance of individualizing treatment plans based on patient needs and response to therapy. This research is like a map, guiding us towards a more proactive and personalized approach to managing RA.

Navigating the Desert of RA: A Path to Relief

This study underscores the importance of early and effective treatment in managing RA, highlighting the benefits of DMARD therapy. This research is like a beacon of hope in the desert of RA, offering a more effective and patient-centered approach to treatment. The authors emphasize the need for continued research to identify the most effective DMARD regimens and refine treatment strategies to maximize patient outcomes.

Dr.Camel's Conclusion

This study provides valuable insights into the management of early RA, highlighting the importance of early intervention with DMARD therapy. This research is like a wellspring of knowledge in the desert of RA, guiding us towards a brighter future for patients seeking relief from this debilitating condition. As we continue to explore this promising frontier, we may uncover new oases of knowledge, leading us closer to effective and personalized treatments for all.
Date :
  1. Date Completed 2004-03-05
  2. Date Revised 2017-01-12
Further Info :

Pubmed ID

14969070

DOI: Digital Object Identifier

14969070

Related Literature

Article Analysis
・Effective treatment of rheumatoid arthritis
SNS
PICO Info
in preparation
Languages

English

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