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The effects of 5-HT on feeding behaviour in mianserin- or cyproheptadine-pretreated rats.

Author: Escartín-PérezR E, López-AlonsoV E, Mancilla-DíazJ M

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study investigated the effects of serotonin (5-HT) on feeding behavior in rats. 5-HT suppressed carbohydrate intake, which was blocked by mianserin and cyproheptadine, indicating that these effects were mediated by 5-HT(1B/2A/1D) and 5-HT(2c) receptors, respectively.
Paper Details　
Original Abstract of the Article :
We examined the effects of 5-HT on the feeding behaviour patterns of rats pretreated with mianserin (5-HT(1B/2A/1D receptor antagonist) or cyproheptadine (a 5-HT(2c) receptor antagonist), injected into the pariventricular hypothalamus nucleus (PVN). The animals were kept at 21 +/- 1 degrees C with a...See full text at original site
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引用元：
https://doi.org/10.1007/BF03325025

データ提供：米国国立医学図書館（NLM）

The Impact of 5-HT on Feeding Behavior

This research delves into the fascinating world of feeding behavior, specifically exploring the role of serotonin (5-HT) in regulating food intake. Imagine a desert nomad, driven by instinct and habit, searching for sustenance in a harsh environment. This study investigates the complex interplay of neurotransmitters and receptors that guide our eating habits.

5-HT's Influence on Carbohydrate Intake

The study reveals that 5-HT plays a significant role in regulating carbohydrate intake, particularly during the natural feeding period. By blocking 5-HT receptors with mianserin and cyproheptadine, researchers observed an increase in carbohydrate consumption, suggesting that 5-HT normally suppresses this intake. These findings highlight the complex interplay of neurochemicals that shape our dietary preferences.

Understanding the Biology of Appetite

This research contributes to our understanding of the biological mechanisms underlying appetite and food intake. By exploring the role of 5-HT in regulating carbohydrate consumption, the study offers insights into potential targets for managing obesity and other eating disorders. It's a reminder that our eating habits are influenced by a complex interplay of biological factors, not just simple willpower.

Dr.Camel's Conclusion

This study reminds us that our appetite is not just a simple matter of hunger, but a complex dance of neurotransmitters and receptors. Understanding the role of 5-HT in regulating food intake opens new doors for exploring strategies to manage obesity and promote healthy eating habits, just like finding a hidden oasis in the vast desert of our bodies.

Date :
  1. Date Completed 2004-04-21
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

15018375

DOI: Digital Object Identifier

10.1007/BF03325025

Related Literature

Article Analysis
・Effects of cyproheptadine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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