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Efficacy of transdermal nitroglycerin combined with etodolac for the treatment of chronic post-thoracotomy pain: an open-label prospective clinical trial.

Author: EidelmanLeonid A, GlantzLucio, GodovicGalina, KramerMordechai, LekarMargarita

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the efficacy of nitroglycerin (NTG) combined with etodolac for the treatment of chronic post-thoracotomy pain (CPP). NTG added to etodolac significantly reduced pain intensity and improved sleep efficiency, with only mild headache as a side effect.
Paper Details　
Original Abstract of the Article :
Chronic post-thoracotomy pain (CPP) is associated with surgical intercostal nerve injury. Like other forms of neuropathic pain, there is no ideal treatment. Nitroglycerin (NTG) has been found efficacious in acute pain, but has not been tested for chronic pain with neuropathic characteristics. The pr...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpainsymman.2003.06.009

データ提供：米国国立医学図書館（NLM）

Chronic Post-Thoracotomy Pain: Exploring New Treatment Options

The lingering pain of [chronic post-thoracotomy pain (CPP)] can feel like a never-ending desert, with few effective treatments available. This study investigates the potential benefits of combining [transdermal nitroglycerin and etodolac] for treating CPP. The researchers embarked on a clinical trial, a journey through the realm of pain management, to assess the effectiveness of this novel treatment approach.

A Promising Combination: NTG and Etodolac for CPP

The study reveals that the combination of NTG and etodolac was effective in reducing pain intensity and improving sleep efficiency in individuals with CPP. This finding suggests that this combination therapy could offer a new avenue for treating this challenging condition.

Hope for Individuals with CPP

This research provides hope for individuals with CPP, suggesting that a combination of NTG and etodolac could offer significant pain relief. The study emphasizes the need for further research to confirm these findings and explore the long-term efficacy and safety of this treatment approach.

Dr. Camel's Conclusion

This research, like a shimmering oasis in a dry desert, offers a glimmer of hope for individuals struggling with chronic post-thoracotomy pain. The combination of NTG and etodolac holds promise for improving pain management and quality of life for those affected by this debilitating condition.

Date :
  1. Date Completed 2004-05-19
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

15038339

DOI: Digital Object Identifier

10.1016/j.jpainsymman.2003.06.009

Related Literature

Article Analysis
・Side Effects of etodolac
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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