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Lack of effect of omeprazole or of an aluminium hydroxide/magnesium hydroxide antacid on the pharmacokinetics of lumiracoxib.
Author: LangholffWayne, MilosavljevSlavica, RordorfChristiane, ScottGraham, ShenoudaMagdy, Vinluan ReynoldsChristine
Original Abstract of the Article :
OBJECTIVE: To evaluate the effects of multiple doses of omeprazole and of a single dose of an aluminium hydroxide/magnesium hydroxide (Al/Mg) antacid on the single-dose plasma pharmacokinetics of lumiracoxib. STUDY DESIGN: Open-label, randomised, three-period, crossover study. POPULATION STUDIED: ...See full text at original site
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引用元:
https://doi.org/10.2165/00003088-200443050-00006
データ提供:米国国立医学図書館(NLM)
The Curious Case of Lumiracoxib: Does Food or Antacids Change Its Course?
In the vast desert of pharmaceutical research, we often find ourselves searching for answers to questions about how drugs interact with our bodies. This study, like a thirsty traveler seeking a cool oasis, dives into the fascinating realm of drug interactions. The researchers used a clever crossover design, like shifting sands constantly changing the landscape, to observe how lumiracoxib, a medication for pain relief, behaved when paired with omeprazole, a stomach acid reducer, or an aluminum/magnesium hydroxide antacid. Their findings were quite illuminating, showing that neither omeprazole nor the antacid had a significant impact on the pharmacokinetics of lumiracoxib.
Lumiracoxib Remains Steady, No Matter the Company
The results indicate that whether lumiracoxib is taken alone, with omeprazole, or with an antacid, its absorption and elimination in the body remain remarkably consistent. This is like a caravan traveling through the desert, the pace and route of the journey are not significantly affected by the presence of different companions along the way.
Good News for Patients: Flexibility in Taking Medications
Knowing that these medications can be taken together without altering their effectiveness is a welcome discovery for both patients and healthcare providers. It simplifies medication management and allows for greater flexibility in treatment plans, creating a smoother journey for patients through their medical regimens.
Dr. Camel's Conclusion
This research, like a well-traveled path through the desert, provides a clear understanding of how lumiracoxib behaves in the presence of other medications. The results offer a comforting oasis of certainty, assuring patients and healthcare professionals that these medications can be combined safely and effectively.
Date :
- Date Completed 2004-08-12
- Date Revised 2018-11-13
Further Info :
Related Literature
English
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