Paper Details

  1. Home
  2. Paper Details

Effects on aqueous flow of dorzolamide combined with either timolol or acetazolamide.

Author: CamrasCarl B, TorisCarol B, YablonskiMichael E, ZhanGui-Lin

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Topical dorzolamide and timolol together were more effective than either drug alone for reducing aqueous flow and lowering intraocular pressure (IOP). The combination of dorzolamide and timolol was more effective than the combination of dorzolamide and acetazolamide.
Paper Details　
Original Abstract of the Article :
PURPOSE: To determine the effect on aqueous flow of topical dorzolamide 2%, topical timolol 0.5%, or oral acetazolamide 250 mg when used alone or when dorzolamide is combined with either timolol or acetazolamide. METHODS: In 30 patients with ocular hypertension, aqueous flow and intraocular pressur...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/00061198-200406000-00006

データ提供：米国国立医学図書館（NLM）

Dorzolamide Combined with Timolol or Acetazolamide: Exploring the Synergistic Effects on Aqueous Flow

This research focuses on the field of ophthalmology, investigating the effects of topical dorzolamide combined with either timolol or acetazolamide on aqueous flow and intraocular pressure (IOP) in patients with ocular hypertension. The authors conducted a crossover study, comparing the effects of these drug combinations on IOP and aqueous flow. The study provides valuable insights into the potential synergistic effects of these medications in managing ocular hypertension.

Dorzolamide and Timolol: A Potent Combination for IOP Reduction

The study found that the combination of dorzolamide and timolol demonstrated significant additivity in reducing aqueous flow and had greater IOP efficacy compared to the combination of dorzolamide and acetazolamide. The researchers observed a significant IOP reduction with both combinations, but the dorzolamide and timolol combination yielded the greatest reduction. This research suggests that the combination of dorzolamide and timolol may be a more effective treatment for ocular hypertension, offering potential benefits for patients seeking to manage their IOP effectively.

Ocular Hypertension: A Desert of Pressure

This research offers a ray of hope in the desert of ocular hypertension, a condition that can lead to vision loss. Just as an oasis provides respite from the harsh desert environment, finding effective treatments for ocular hypertension can protect precious eyesight. This study highlights the potential of drug combinations to enhance IOP reduction, offering a valuable tool for managing this condition.

Dr. Camel's Conclusion

This research is like a map guiding us through the complex landscape of ocular hypertension treatments. It reveals the potential of drug combinations to enhance IOP reduction and offers valuable insights for managing this condition effectively.

Date :
  1. Date Completed 2004-06-21
  2. Date Revised 2019-11-08
Further Info :

Pubmed ID

15118464

DOI: Digital Object Identifier

10.1097/00061198-200406000-00006

Related Literature

Article Analysis
・Effects of timolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.