Paper Details 
Original Abstract of the Article :
1. The aim of the present study was to analyse the inhibitory effects of dihydroergotamine, cyproheptadine and ketanserin on the rat aorta contractile responses to 5-HT. Initially phenoxybenzamine treatment was used to determine whether spare receptors exist at the maximum responses to 5-HT. Then th...See full text at original site
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引用元:
https://doi.org/10.1111/j.1474-8673.1992.tb00336.x

データ提供:米国国立医学図書館(NLM)

Unveiling the Inhibitory Effects of Dihydroergotamine, Cyproheptadine, and Ketanserin on Rat Aorta Responses to 5-Hydroxytryptamine: A Camel's Journey Through the Vasculature

The world of cardiovascular research, like a vast desert landscape, is filled with intricate pathways and complex interactions. This study, like a skilled desert explorer, investigates the inhibitory effects of various drugs on the contractile responses of rat aortas to 5-hydroxytryptamine (5-HT), a neurotransmitter that plays a crucial role in regulating vascular tone. The researchers, like meticulous cartographers mapping an uncharted territory, meticulously analyzed the effects of dihydroergotamine, cyproheptadine, and ketanserin on the fast and slow responses of the rat aorta to 5-HT.

Unlocking the Secrets of Vascular Contraction: A Camel's Perspective

The research, like a camel uncovering a hidden oasis, revealed that these drugs effectively inhibited the contractile responses of the rat aorta to 5-HT, suggesting their potential as therapeutic agents for conditions involving vascular dysfunction. The study further identified key differences in the reversibility of their inhibitory effects, highlighting the importance of understanding the specific mechanisms of action of these drugs for optimizing their use in clinical settings.

Navigating the Vasculature: A Camel's Wisdom

This research, like a compass guiding us through the complexities of vascular physiology, provides valuable insights into the interactions between specific drugs and the vascular system. The findings underscore the importance of understanding the nuances of drug-receptor interactions and the potential for drug-induced effects on vascular function, information that can be crucial for guiding therapeutic decisions and ensuring patient safety.

Dr.Camel's Conclusion

This study provides a detailed analysis of the inhibitory effects of dihydroergotamine, cyproheptadine, and ketanserin on the contractile responses of rat aortas to 5-hydroxytryptamine. The findings offer valuable insights into the specific mechanisms of action of these drugs and their potential therapeutic applications in managing conditions involving vascular dysfunction.

Date :
  1. Date Completed 1992-10-01
  2. Date Revised 2019-10-28
Further Info :

Pubmed ID

1512277

DOI: Digital Object Identifier

10.1111/j.1474-8673.1992.tb00336.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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