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A prospective randomized observer-blind 2-year trial of azathioprine monotherapy versus azathioprine and olsalazine for the maintenance of remission of steroid-dependent ulcerative colitis.

Author: ArchavlisEmmanuel, ChristidouAngeliki, KaragiannidisAlexandros, MantzarisGerassimos J, PetrakiKalliopi, SfakianakisMichael, TriadaphyllouGeorge

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effectiveness of azathioprine (AZA) alone or in combination with olsalazine in maintaining remission of steroid-dependent ulcerative colitis (UC). The study found that AZA alone was as effective as AZA combined with olsalazine in maintaining remission, but that the combination therapy was associated with more adverse events, higher cost, and poorer compliance.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The aim of this prospective study was to assess whether the coadministration of azathioprine (AZA) and olsalazine is superior to AZA monotherapy in maintaining remission of steroid-dependent ulcerative colitis (UC). METHODS: Patients with steroid-dependent UC in remission were randomized...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15180735

データ提供：米国国立医学図書館（NLM）

Ulcerative Colitis: A Journey Through the Desert of Inflammation

Ulcerative colitis, a chronic inflammatory bowel disease, can be a difficult and unpredictable journey through the desert of inflammation. This study investigates the effectiveness of two different treatment approaches for maintaining remission in patients with steroid-dependent ulcerative colitis. The researchers compared the effectiveness of azathioprine alone versus a combination of azathioprine and olsalazine in preventing relapse.

A Crossroads in Treatment: Exploring Different Pathways for Ulcerative Colitis

The study found that both treatment approaches, azathioprine alone and the combination therapy, were equally effective in maintaining remission in patients with steroid-dependent ulcerative colitis. This finding provides valuable information for physicians when deciding on the best treatment strategy for individual patients. It's like reaching a crossroads in the desert, where both paths offer potential for safe passage, but the choice depends on the specific needs of the traveler.

Finding the Right Path: Personalized Care for Ulcerative Colitis

This study underscores the importance of personalized care in treating ulcerative colitis. Each patient's journey through the desert of inflammation is unique, and finding the right treatment approach requires careful consideration of their individual needs and circumstances. This is a reminder that the best approach is not always the most complex, but rather the one that best fits the specific needs of the traveler.

Dr.Camel's Conclusion

This study provides valuable insights into the management of steroid-dependent ulcerative colitis, a challenging condition for many patients. The research highlights the importance of personalized care and the need to carefully consider the best treatment approach for each individual, just as a wise traveler chooses the path that best suits their needs in the vast desert landscape.

Date :
  1. Date Completed 2004-08-06
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

15180735

DOI: Digital Object Identifier

AJG11481

Related Literature

Article Analysis
・Side Effects of olsalazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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