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Induced sputum in children with newly diagnosed mild asthma: the effect of 6 months of treatment with budesonide or disodium cromoglycate.

Author: HaahtelaT, MetsoT, NikanderK, PelkonenA S, RytiläP, TurpeinenM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sputum eosinophilia is present in children with newly diagnosed mild persistent asthma. Inhaled budesonide, but not disodium cromoglycate, decreases sputum eosinophils and improves clinical and functional outcomes.
Paper Details　
Original Abstract of the Article :
BACKGROUND: There are few controlled studies on the effects of anti-inflammatory treatment on airway inflammation in newly diagnosed childhood asthma. METHODS: Sixty children with newly diagnosed mild persistent asthma, 5-10 years of age, and 17 healthy control subjects were studied. Asthmatic chil...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15230816

データ提供：米国国立医学図書館（NLM）

Sputum Eosinophilia in Childhood Asthma: A Desert of Inflammation

Childhood asthma, a chronic respiratory condition affecting millions of children worldwide, is a challenging terrain in the desert of pediatric medicine. This research delves into the role of sputum eosinophilia, a marker of airway inflammation, in newly diagnosed mild asthma in children. The study found that sputum eosinophilia is present in children with newly diagnosed mild asthma and that treatment with inhaled budesonide, but not disodium cromoglycate (DSCG), effectively reduced sputum eosinophils and improved clinical outcomes. These findings, like a well-timed oasis in the desert of asthma treatment, offer hope for improved management and potentially better outcomes for children with asthma.

Navigating the Desert of Asthma: A Focus on Inflammation

This research highlights the importance of addressing airway inflammation in children with asthma. The study suggests that sputum eosinophilia is a valuable marker for identifying children who might benefit from inhaled corticosteroids like budesonide. This finding is like finding a hidden oasis in the desert of asthma treatment, offering a new and potentially more effective way to manage this common childhood condition.

A Doctor's Perspective on Childhood Asthma Management

This research emphasizes the importance of a personalized approach to managing childhood asthma, considering the individual needs and characteristics of each patient. Like a skilled desert guide, a doctor must carefully assess the child's symptoms, monitor their response to treatment, and tailor therapies to optimize their outcomes. This personalized approach, coupled with a deep understanding of asthma pathogenesis and a commitment to patient well-being, can help children navigate the complexities of this disease, ultimately achieving better outcomes and improving their quality of life.

Dr. Camel's Conclusion

This study provides valuable insights into the role of sputum eosinophilia in childhood asthma, highlighting the potential benefits of inhaled budesonide in reducing inflammation and improving clinical outcomes. The research emphasizes the importance of personalized approaches to managing childhood asthma, considering the individual needs and characteristics of each patient.
Date :
  1. Date Completed 2005-02-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15230816

DOI: Digital Object Identifier

ALL504

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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