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A double blind comparison of intranasal budesonide 400 micrograms and 800 micrograms in perennial rhinitis.

Author: AnderssonB, BeckinghamE, EkL, JonesA S, WightR G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Budesonide nasal spray, at doses of 400 micrograms and 800 micrograms daily, improved nasal obstruction in patients with rhinitis, with no significant difference between the two doses. Both doses were well tolerated and did not affect plasma cortisol levels.
Paper Details　
Original Abstract of the Article :
A randomized double blind placebo controlled cross-over study comparing budesonide 400 micrograms and budesonide 800 micrograms daily in 59 patients is presented. Nasal obstruction was the predominant symptom and was subjectively and objectively improved by both doses of budesonide (P less than 0.00...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2273.1992.tb01012.x

データ提供：米国国立医学図書館（NLM）

Budesonide for Perennial Rhinitis: A Cool Breeze in the Desert of Allergies

Perennial rhinitis, a persistent nasal inflammation, can significantly impact quality of life. This research investigates the efficacy of budesonide, a nasal corticosteroid, in treating perennial rhinitis. The authors conducted a randomized, double-blind, placebo-controlled crossover study to compare the effectiveness of two different doses of budesonide in patients with perennial rhinitis.

Budesonide: A Reliable Remedy for Nasal Obstruction

The study demonstrates the effectiveness of budesonide in alleviating nasal obstruction, a common symptom of perennial rhinitis. Both doses of budesonide significantly improved nasal obstruction, both subjectively and objectively, suggesting that budesonide is a reliable treatment option for this condition. Importantly, the study found no significant difference in efficacy between the two doses, indicating that lower doses may be equally effective.

Finding Relief in the Desert of Allergies

This research offers valuable insights into the treatment of perennial rhinitis, providing evidence for the effectiveness of budesonide in alleviating nasal obstruction. The authors' findings highlight the importance of considering nasal corticosteroids as a primary treatment option for this common condition. Just as a camel finds respite from the heat in a cool oasis, so too might patients with perennial rhinitis find relief through the use of budesonide.

Dr.Camel's Conclusion

This study offers a cool breeze in the desert of allergies. The findings highlight the effectiveness of budesonide in alleviating nasal obstruction, a common and debilitating symptom of perennial rhinitis. The research underscores the importance of considering nasal corticosteroids as a primary treatment option, providing hope for patients seeking relief from the relentless discomfort of allergies.

Date :
  1. Date Completed 1992-10-22
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

1526057

DOI: Digital Object Identifier

10.1111/j.1365-2273.1992.tb01012.x

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Article Analysis
・Effects of budesonide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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