Effects of budesonide: A Synthesis of Findings from 42 Studies

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Original Abstract of the Article

Major Research Findings

Budesonide has been shown to be effective in treating a variety of diseases, including asthma, hay fever, and Crohn's disease. 2 shows that budesonide is an effective treatment for infants who may need prophylaxis for their wheezing. 37 demonstrates that budesonide/formoterol combination therapy has a positive effect on symptoms in adults with mild-to-moderate persistent asthma. 39 suggests that budesonide/formoterol combination therapy might affect airway dimensions and inflammation in individuals with asthma. 42 highlights the potential of budesonide in combination with fluvoxamine for treating early-onset COVID-19. 12 shows that intranasal budesonide effectively reduces nasal symptoms in patients with hay fever. 13 indicates that the dosing frequency and schedule of budesonide can influence its efficacy and safety in treating asthma. Research has also investigated budesonide's efficacy in various forms and settings, including oral formulations 41 , nebulized delivery 18 , and different doses 10 . Additionally, research has compared budesonide with other treatments, such as prednisolone 14 , beclomethasone dipropionate 15 , fluticasone propionate 25 , and other inhaled corticosteroids 28 .

Benefits and Risks

Benefit Summary

Budesonide has shown effectiveness in treating a variety of respiratory conditions, including asthma, hay fever, and chronic wheezing in infants. It can improve symptoms, reduce exacerbations, and potentially prevent disease progression in some cases. Studies have also highlighted the potential of budesonide in treating Crohn's disease and reducing nasal symptoms associated with hay fever. The drug's effectiveness has been shown in different forms, including inhaled, intranasal, and oral formulations. It can be used as a maintenance treatment, as needed during exacerbations, and as a combination therapy with other medications. The potential of budesonide in treating COVID-19 is also being explored.

Risk Summary

While budesonide is generally considered safe, some patients may experience side effects. These can include oral thrush, hoarseness, cough, and in rare cases, meningitis. The severity of these side effects can vary depending on the dosage, route of administration, and individual patient factors. It is important to consult with a doctor to determine the appropriate dosage and route of administration and to monitor for any potential side effects.

Comparison of Studies

Commonalities

Most studies on budesonide have consistently shown its effectiveness in treating asthma and other respiratory conditions. These studies highlight its ability to improve symptoms, reduce exacerbations, and offer a potential alternative to oral corticosteroids. They have also explored budesonide's effectiveness in different forms and dosages, providing a wider range of treatment options for healthcare providers.

Differences

The research on budesonide shows some variation in terms of specific dosages, delivery methods, and patient groups. For example, the efficacy of budesonide has been assessed in different age groups, including infants, children, and adults. Studies have also investigated the impact of various factors, such as dosing frequency, inhaled versus oral administration, and combination therapy with other medications. These variations in research methodology contribute to the ongoing efforts to optimize budesonide treatment for different patient needs.

Consistency and Contradictions of Results

The majority of the research on budesonide supports its safety and efficacy in treating asthma and related conditions. However, some studies highlight potential side effects, such as oral thrush, hoarseness, and cough. While these side effects are generally mild and manageable, it is crucial for healthcare providers to be aware of them and to carefully monitor patients for any adverse reactions. The overall consistency of research findings suggests that budesonide is a valuable treatment option for many respiratory conditions, but further research is needed to fully understand its long-term effects and optimal use in diverse patient populations.

Considerations for Real-World Application

Budesonide can be a valuable tool for managing asthma, hay fever, and other respiratory conditions. It is important to consult with a doctor to determine the appropriate dosage and route of administration. They can also advise on any potential side effects and how to manage them. It's also important to discuss any existing health conditions or allergies with your doctor before starting budesonide treatment.

Limitations of Current Research

Further research is needed to fully understand the long-term effects of budesonide, particularly on various age groups and in individuals with different health conditions. More research is also needed to optimize budesonide treatment for specific patient needs, such as determining the optimal dosage and delivery methods for various conditions.

Future Research Directions

Future research should focus on: * Exploring the long-term effects of budesonide, including potential side effects and long-term efficacy. * Investigating the optimal dosage and delivery methods for different patient groups and conditions. * Evaluating budesonide's potential for use in combination with other medications, particularly for treating more complex conditions. * Exploring budesonide's potential for treating other respiratory conditions or disease areas beyond those already studied.

Conclusion

Budesonide is a safe and effective medication for managing a variety of respiratory conditions. It can improve symptoms, reduce exacerbations, and offer a potential alternative to oral corticosteroids. However, it's essential to consult with a doctor to determine the appropriate dosage and route of administration. Budesonide treatment should be carefully monitored for any potential side effects. Further research is needed to fully understand its long-term effects and potential for treating other conditions.

Keywords
Benefit Keywords
Nasal obstruction relief
1
Infant treatment
Wheezing prophylaxis
2
Improved asthma control
Reduced bronchial hyperreactivity
3
Asthma treatment
5
Decreased eosinophils
Suppressed cortisol levels
6
Budesonide efficacy
7
Asthma treatment
8
Antiasthmatic efficacy
Low systemic glucocorticoid activity
9
Bronchial hyperreactivity treatment
10
Improved asthma
11
Budesonide efficacy
Nasal symptom reduction
12
Asthma treatment
13
Crohn's disease remission
Reduced side effects
14
Asthma treatment
Inhaled steroid efficacy
15
Asthma control in young children
16
Improved lung function
Reduced symptoms
17
Reduced systemic effects
Topical anti-inflammatory activity
18
Asthma control
Better lung function
Improved symptoms
19
Asthma relief
Slower decline on cessation
20
Efficient nebulized budesonide
21
Decreased bronchial hyperresponsiveness
22
Asthma treatment
23
Reduced asthma symptoms
24
Asthma symptom control
Peak expiratory flow improvement
25
Control asthma symptoms
26
Reduced relapse rate
27
Improved FEV1
28
Asthma treatment
29
Asthma treatment
32
Improved lung function
Reduced BHR
Reduced asthma symptoms
33
Improved Crohn's disease
34
Attenuated LAR
Reduced airway hyperresponsiveness
35
Crohn's disease remission
Limited side effects
36
Improved asthma control
37
Asthma control
Exacerbation reduction
38
Asthma symptom control
39
Anti-inflammatory effects
Asthma control
Improved FEV1
40
less systemic side effects
ulcerative colitis remission
41
COVID-19 treatment
Disease progression prevention
42
Risk Keywords
Exacerbations
Meningitis
2
Eosinophilia
3
Bone complications
Bone turnover
4
Cough
Disability due to asthma
Nocturnal asthma
7
Cough
Hoarseness
Oropharyngeal candidiasis
8
Steroid-induced complications
9
Side effects
10
Mild side effects
12
Hypothalamic-pituitary-adrenal function impairment
13
Abdominal-wall fistula
Intestinal perforation
14
High dose steroids
15
Side effects
16
Rapid decline on cessation
20
Dose-related adverse effects
21
Nedocromil sodium and salmeterol ineffective
22
Adrenal suppression
Bone suppression
Hematologic suppression
23
Growth reduction
25
Systemic side effects
27
Long-term adverse effects
Systemic absorption
30
Increased systemic exposure
31
HPA axis suppression
32
None reported
33
Mild side effects
34
Eosinophil increase
38
Gastric irritation
40
adverse effects
41
Adverse events
Vaccinated population
42
Literature analysis of 42 papers
Positive Content
39
Neutral Content
1
Negative Content
2
Article Type
41
1
1
1
42
1.

A double blind comparison of intranasal budesonide 400 micrograms and 800 micrograms in perennial rhinitis.

Author: WightR G, JonesA S, BeckinghamE, AnderssonB, EkL

Nasal obstruction relief

Budesonide nasal spray, at doses of 400 micrograms and 800 micrograms daily, improved nasal obstruction in patients with rhinitis, with no significant difference between the two doses. Both doses were well tolerated and did not affect plasma cortisol levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Inhaled budesonide for chronic wheezing under 18 months of age.

Author: NobleV, RugginsN R, EverardM L, MilnerA D

Infant treatment
Wheezing prophylaxis
Exacerbations
Meningitis

Budesonide delivered via a metered dose inhaler into a large volume spacer was effective in controlling chest symptoms in infants.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Short-term treatment of asthma with budesonide versus placebo.

Author: Estrada RodríguezJ L, Belchi HernándezJ, Florido LópezJ F, López SerranoC, Martínez AlzamoraF, Ojeda CasasJ A

Improved asthma control
Reduced bronchial hyperreactivity
Eosinophilia

The study evaluated the effects of the topical steroid budesonide on bronchial hyperreactivity in patients with asthma. Budesonide improved asthma control and lung function, but its effect on bronchial hyperreactivity was modest.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Effects of dose and dosing schedule of inhaled budesonide on bone turnover.

Author: ToogoodJ H, JenningsB, HodsmanA B, BaskervilleJ, FraherL J

Bone complications
Bone turnover

Budesonide, an inhaled steroid, reduced serum osteocalcin levels, suggesting an inhibitory effect on bone formation. The clinical significance of this effect requires further investigation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Adrenal function in asthmatic children treated with inhaled budesonide.

Author: BisgaardH, PedersenS, Damkjaer NielsenM, OsterballeO

Asthma treatment

Budesonide, an inhaled topical steroid, did not cause significant adrenal suppression in asthmatic children, demonstrating a favorable ratio between topical and systemic effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Assessment of the systemic effects of inhaled glucocorticosteroids: the influence of blood sampling technique and frequency on plasma cortisol and leucocytes.

Author: JenningsB H, AnderssonK E, JohanssonS A

Decreased eosinophils
Suppressed cortisol levels

Budesonide, an inhaled corticosteroid, suppressed both plasma and urine free cortisol and delayed the nocturnal rise in cortisol levels. In a randomized, double-blind, cross-over study of 12 healthy males, budesonide also decreased lymphocytes, eosinophils, and monocytes while increasing neutrophils and total white blood cells.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Four-times-a-day dosing frequency is better than a twice-a-day regimen in subjects requiring a high-dose inhaled steroid, budesonide, to control moderate to severe asthma.

Author: MaloJ L, CartierA, MerlandN, GhezzoH, BurekA, MorrisJ, JenningsB H

Budesonide efficacy
Cough
Disability due to asthma
Nocturnal asthma

Budesonide delivered twice a day showed higher rates of nocturnal asthma, cough, and disability due to asthma compared to four times a day, suggesting a potential dose-related effect on asthma control.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Comparison of dose-response effects of inhaled beclomethasone dipropionate and budesonide in the management of asthma.

Author: BoeJ, RosenhallL, AltonM, CarlssonL G, CarlssonU, HermanssonB A, HettaL, KiviloogJ, KarlsonB W, LundbäckB

Asthma treatment
Cough
Hoarseness
Oropharyngeal candidiasis

Inhaled beclomethasone dipropionate (BDP) and budesonide (BUD) are both effective in treating asthma. In a multi-centre, double-blind, cross-over study of 128 patients, both drugs showed comparable efficacy at high and low doses. Adverse effects, mainly oropharyngeal candidiasis, hoarseness, and cough, occurred in 12% of treatment months.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Bioequivalent doses of budesonide and prednisone in moderate and severe asthma.

Author: ToogoodJ H, BaskervilleJ, JenningsB, LefcoeN M, JohanssonS A

Antiasthmatic efficacy
Low systemic glucocorticoid activity
Steroid-induced complications

Inhaled budesonide was equally effective as oral prednisone in treating asthma, but at lower doses, resulting in less systemic glucocorticoid activity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Dosage and time effects of inhaled budesonide on bronchial hyperreactivity.

Author: KraanJ, KoëterG H, van der MarkT W, BoorsmaM, KuklerJ, SluiterH J, De VriesK

Bronchial hyperreactivity treatment
Side effects

Inhaled budesonide was effective in reducing bronchial hyperreactivity in allergic asthmatic patients. The effect was dose-dependent, with a higher dose (800 micrograms/day) producing a larger change in methacholine provocation concentrations than a lower dose (200 micrograms/day).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

A double-blind dose-response study of budesonide by inhalation in patients with bronchial asthma.

Author: JohanssonS A, DahlR

Improved asthma

Budesonide inhalation was effective in treating moderate chronic bronchial asthma. The effectiveness of the treatment was dose-dependent. No side effects were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Treatment of grass pollen-induced hay fever with intranasal budesonide. A double-blind clinical comparison between budesonide and placebo.

Author: SteensenH, LindqvistN

Budesonide efficacy
Nasal symptom reduction
Mild side effects

Intranasal budesonide effectively reduced nasal symptoms in patients with hay fever, with 200 micrograms daily being sufficient. No significant eye symptoms or changes in plasma cortisol were observed. Only mild side effects were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Influence of dosing frequency and schedule on the response of chronic asthmatics to the aerosol steroid, budesonide.

Author: ToogoodJ H, BaskervilleJ C, JenningsB, LefcoeN M, JohanssonS A

Asthma treatment
Hypothalamic-pituitary-adrenal function impairment

Budesonide, an aerosol corticosteroid, demonstrated a dose-dependent effect on antiasthmatic and systemic effects. Higher doses were associated with increased efficacy, but also greater systemic effects. A q.i.d. A.M./P.M. dosing regimen provided the best risk-benefit relationship.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

A comparison of budesonide with prednisolone for active Crohn's disease.

Author: RutgeertsP, LöfbergR, MalchowH, LamersC, OlaisonG, JewellD, DanielssonA, GoebellH, ThomsenO O, Lorenz-MeyerH

Crohn's disease remission
Reduced side effects
Abdominal-wall fistula
Intestinal perforation

Budesonide and prednisolone were both effective in inducing remission in Crohn's disease patients. Budesonide was associated with fewer glucocorticoid-associated side effects and less suppression of pituitary-adrenal function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Effect of eight months of inhaled beclomethasone dipropionate and budesonide on carbohydrate metabolism in adults with asthma.

Author: KivirantaK, TurpeinenM

Asthma treatment
Inhaled steroid efficacy
High dose steroids

The study investigated the efficacy and safety of high-dose inhaled steroids (beclomethasone dipropionate and budesonide) in adults with unstable asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Nebulized budesonide for the treatment of moderate to severe asthma in infants and toddlers.

Author: WennergrenG, NordvallS L, HedlinG, MöllerC, WilleS, Asbrink NilssonE

Asthma control in young children
Side effects

Nebulized budesonide was found to be effective in controlling asthma in young children. A higher starting dose did not lead to faster symptom control, highlighting the importance of treatment duration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Effect of regular terbutaline on the airway response to inhaled budesonide.

Author: WildingP J, ClarkM M, OborneJ, BennettJ A, TattersfieldA E

Improved lung function
Reduced symptoms

The study examines the effects of budesonide alone and in combination with regular terbutaline treatment on lung function, symptoms, and bronchial reactivity in asthmatic patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

A comparison of nebulized budesonide with oral prednisolone in the treatment of exacerbations of obstructive pulmonary disease.

Author: MoriceA H, MorrisD, Lawson-MatthewP

Reduced systemic effects
Topical anti-inflammatory activity

Nebulized budesonide was associated with fewer corticosteroid side effects compared to oral prednisolone in patients with severe acute airway obstruction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.

Author: PauwelsR A, LöfdahlC G, PostmaD S, TattersfieldA E, O'ByrneP, BarnesP J, UllmanA

Asthma control
Better lung function
Improved symptoms

Adding inhaled formoterol to budesonide therapy, or using a higher dose of budesonide, was beneficial for patients with persistent asthma symptoms despite treatment with inhaled glucocorticoids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Immunotherapy vs inhaled budesonide in bronchial asthma: an open, parallel, comparative trial.

Author: ShaikhW A

Asthma relief
Slower decline on cessation
Rapid decline on cessation

Inhaled corticosteroids provided faster relief for bronchial asthma than immunotherapy, but the benefit declined more rapidly after cessation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Comparative study of budesonide as a nebulized suspension vs pressurized metered-dose inhaler in adult asthmatics.

Author: BisgaardH, NikanderK, MunchE

Efficient nebulized budesonide
Dose-related adverse effects

Nebulized budesonide was found to be as effective as budesonide administered with a spacer in treating adult asthmatics. The nebulized treatment was at least as efficient as the pMDI plus spacer treatment and the apparent order of effect was 4 mg nebulized suspension treatment > or = 1 mg nebulized suspension treatment > or = 0.8 mg pMDI with spacer treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Short-term effects of budesonide, nedocromil sodium and salmeterol on bronchial hyperresponsiveness in childhood asthma.

Author: BakiA, KaragüzelG

Decreased bronchial hyperresponsiveness
Nedocromil sodium and salmeterol ineffective

Budesonide, but not nedocromil sodium or salmeterol, decreases bronchial hyperresponsiveness in children with mild-to-moderate asthma over a three-week period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Systemic bioactivity profiles of oral prednisolone and nebulized budesonide in adult asthmatics.

Author: WilsonA M, McFarlaneL C, LipworthB J

Asthma treatment
Adrenal suppression
Bone suppression
Hematologic suppression

For all three systemic bioactivity markers (8 AM plasma cortisol, serum osteocalcin, and blood eosinophils), there was significant dose-related suppression with prednisolone but not with budesonide. In a study of 12 asthmatic patients, regression analysis showed significant dose-related suppression with prednisolone for 8 AM plasma cortisol, osteocalcin, and blood eosinophil count, but not with budesonide.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Systemic effects of a short course of betamethasone compared with high-dose inhaled budesonide in early childhood asthma.

Author: HedlinG, SvedmyrJ, RydenA C

Reduced asthma symptoms

This study found that 10 days of high-dose inhaled budesonide did not produce significant systemic effects in children with asthma, while a 3-day course of oral betamethasone had pronounced systemic effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Efficacy and safety of high-dose inhaled steroids in children with asthma: a comparison of fluticasone propionate with budesonide.

Author: FergusonA C, SpierS, ManjraA, VersteeghF G, MarkS, ZhangP

Asthma symptom control
Peak expiratory flow improvement
Growth reduction

Inhaled fluticasone propionate at half the dose was superior to budesonide in improving peak expiratory flow in children with asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Low-dose budesonide with the addition of an increased dose during exacerbations is effective in long-term asthma control. On behalf of the Italian Study Group.

Author: ForesiA, MorelliM C, CatenaE

Control asthma symptoms

This study compared the effectiveness of low and standard doses of budesonide in managing asthma symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

A randomized, controlled trial of high dose, inhaled budesonide versus oral prednisone in patients discharged from the emergency department following an acute asthma exacerbation.

Author: FitzGeraldJ M, ShraggeD, HaddonJ, JenningsB, LeeJ, BaiT, PareP, KassenD, GrunfeldA

Reduced relapse rate
Systemic side effects

This study compared the effectiveness of prednisone and budesonide on relapse rate after emergency treatment for an asthmatic attack. Budesonide was well-tolerated and may be a better option than prednisone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Comparison of efficacy and safety between flunisolide/AeroChamber and budesonide/turbuhaler in patients with moderate asthma. AER-MD-04 Study Group.

Author: NewhouseM, KnightA, WangS, NewmanK

Improved FEV1

Flunisolide administered via AeroChamber and budesonide administered via Turbuhaler demonstrated similar efficacy and safety in treating moderate asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Therapeutic ratio of inhaled corticosteroids in adult asthma. A dose-range comparison between fluticasone propionate and budesonide, measuring their effect on bronchial hyperresponsiveness and adrenal cortex function.

Author: NielsenL P, DahlR

Asthma treatment

Fluticasone propionate (FP) is more effective than budesonide (BUD) in treating asthma, with a higher therapeutic ratio based on its impact on bronchial responsiveness and endogenous corticosteroid production. FP was more potent than BUD in reducing bronchial responsiveness, while having less impact on endogenous cortisol secretion.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Comparison of the systemic effects of fluticasone propionate and budesonide given by dry powder inhaler in healthy and asthmatic subjects.

Author: HarrisonT W, WisniewskiA, HonourJ, TattersfieldA E

Long-term adverse effects
Systemic absorption

This study compared the systemic effects of fluticasone propionate and budesonide, two inhaled corticosteroids, in healthy and asthmatic subjects. The effects of treatment on three systemic markers were investigated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Plasma concentrations of inhaled budesonide and its effects on plasma cortisol are increased by the cytochrome P4503A4 inhibitor itraconazole.

Author: RaaskaKari, NiemiMikko, NeuvonenMikko, NeuvonenPertti J, KivistöKari T

Increased systemic exposure

Itraconazole markedly increased systemic exposure to inhaled budesonide, probably by inhibiting the cytochrome P4503A4-mediated metabolism of budesonide.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Study on serum and urinary cortisol levels of asthmatic patients after treatment with high dose inhaled beclomethasone dipropionate or budesonide.

Author: KaurCharanjeet, BansalS K, ChhabraS K

Asthma treatment
HPA axis suppression

Inhaled corticosteroids can be absorbed systemically, potentially leading to adverse effects. The study compared beclomethasone dipropionate (BDP) and budesonide (BUD) and found that they had similar effects on HPA axis suppression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

[The long term effect of small dose budesonide turbuhaler on mild bronchial asthma].

Author: WengJun-liang, ZhengYi-shan, MaQiong-feng

Improved lung function
Reduced BHR
Reduced asthma symptoms
None reported

Long-term, low-dose budesonide turbuhaler inhalation was effective in decreasing bronchial hyperreactivity and improving pulmonary function in patients with mild bronchial asthma. The treatment did not suppress the hypothalamic-pituitary-adrenal axis function.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

34.

Beclomethasone dipropionate for the treatment of mild-to-moderate Crohn's disease: an open-label, budesonide-controlled, randomized study.

Author: TursiAntonio, GiorgettiGian Marco, BrandimarteGiovanni, EliseiWalter, AielloFabio

Improved Crohn's disease
Mild side effects

Beclomethasone dipropionate was less effective than budesonide in treating Crohn's disease, likely due to better pharmacokinetic properties of budesonide.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

The effects of inhaled budesonide and formoterol in combination and alone when given directly after allergen challenge.

Author: DuongMyLinh, GauvreauGail, WatsonRichard, ObminskiGeorge, StrinichTara, EvansMichelle, HowieKaren, KillianKieran, O'ByrnePaul M

Attenuated LAR
Reduced airway hyperresponsiveness

A single dose of budesonide/formoterol was superior to its monocomponents in attenuating the allergen-induced late airway response and airway hyperresponsiveness in patients with mild asthma. The protective effect against allergic airway responses with a single reliever dose of budesonide/formoterol is predominantly related to greater functional antagonism of airway smooth muscles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Maintenance treatment with budesonide 6 mg versus 9 mg once daily in patients with Crohn's disease in remission.

Author: de JongD J, BacD J, TanG, de BoerS Y, GrabowskyI L F, JansenJ B M J, GreinwaldR, NaberT H J

Crohn's disease remission
Limited side effects

Budesonide 9 mg once daily is as effective as 6 mg daily in maintaining remission in patients with quiescent Crohn's disease, with similar side effect profiles.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

The effect of budesonide and formoterol in one pressurized metered-dose inhaler on patient-reported outcomes in adults with mild-to-moderate persistent asthma.

Author: MurphyKevin, NelsonHarold, ParasuramanBhash, BoggsRobert, MillerChristopher, O'DowdLiza

Improved asthma control

Budesonide/formoterol pMDI significantly improved asthma-related quality of life, sleep quality, and asthma control compared to placebo. It also demonstrated greater satisfaction with treatment than other treatment groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

Airway inflammation in patients with asthma with high-fixed or low-fixed plus as-needed budesonide/formoterol.

Author: PavordIan D, JefferyPeter K, QiuYusheng, ZhuJie, ParkerDebbie, CarlsheimerAsa, NayaIan, BarnesNeil C

Asthma control
Exacerbation reduction
Eosinophil increase

Budesonide/formoterol maintenance and reliever therapy is associated with higher eosinophil counts compared with fixed-dose combination treatment containing a 4-fold higher maintenance dose of budesonide, but these remain within the range associated with stable clinical control.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Effects of budesonide/formoterol combination therapy versus budesonide alone on airway dimensions in asthma.

Author: HoshinoMakoto, OhtawaJunichi

Asthma symptom control

Budesonide/formoterol combination therapy in individuals with asthma demonstrated more favorable effects on airway dimensions and inflammation compared to budesonide alone.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Budesonide/formoterol maintenance and reliever therapy in asthma control: acute, dose-related effects and real-life effectiveness.

Author: LinChing-Hsiung, HsuJeng-Yuan, HsiaoYi-Han, TsengChing-Min, SuVincent Yi-Fong, ChenYu-Hsuan, YangSheau-Ning, LeeYu-Chin, SuKang-Cheng, PerngDiahn-Warng

Anti-inflammatory effects
Asthma control
Improved FEV1
Gastric irritation

Budesonide/formoterol maintenance and reliever therapy (BFMRT) showed acute, dose-related anti-inflammatory effects and improvements in forced expiratory volume in first second (FEV1) in symptomatic asthmatics. BFMRT was effective in asthma control over a 24-week maintenance phase. However, the long-term follow-up rate declined, highlighting the need for strategies to improve adherence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Oral budesonide for induction of remission in ulcerative colitis.

Author: SherlockMary E, MacDonaldJohn K, GriffithsAnne Marie, SteinhartA Hillary, SeowCynthia H

less systemic side effects
ulcerative colitis remission
adverse effects

This study compares the efficacy and safety of three different formulations of budesonide, a topically acting corticosteroid, for induction of remission in ulcerative colitis. The study discusses the advantages and disadvantages of each formulation, focusing on their potential for reducing systemic side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19 : A Randomized Platform Trial.

Author: ReisGilmar, Dos Santos Moreira SilvaEduardo Augusto, Medeiros SilvaDaniela Carla, ThabaneLehana, de Souza CamposVitoria Helena, FerreiraThiago Santiago, Quirino Dos SantosCastilho Vitor, Ribeiro NogueiraAna Maria, Figueiredo Guimaraes AlmeidaAna Paula, Cançado Monteiro SavassiLeonardo, de Figueiredo NetoAdhemar Dias, BitarãesCarina, Cruz MilagresAline, Diniz CallegariEduardo, Campos SimplicioMaria Izabel, Barra RibeiroLuciene, OliveiraRosemary, HarariOfir, WilsonLindsay A, ForrestJamie I, RutonHinda, SpragueSheila, McKayPaula, GuoChristina M, GuyattGordon H, RaynerCraig R, BoulwareDavid R, EzerNicole, LeeTodd C, McDonaldEmily Gibson, BafadhelMona, ButlerChristopher, Rodrigues SilvaJosue, DybulMark, MillsEdward J,

COVID-19 treatment
Disease progression prevention
Adverse events
Vaccinated population

This randomized controlled trial evaluated the efficacy of fluvoxamine plus inhaled budesonide for preventing disease progression in high-risk outpatients with early COVID-19. The study found that the combination treatment significantly reduced the incidence of severe disease requiring advanced care, with a probability of superiority of 98.7%. No significant differences were found between the groups for secondary outcomes. The study concluded that fluvoxamine plus inhaled budesonide is a promising treatment option for reducing severe COVID-19 in high-risk outpatients.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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