Paper Details

  1. Home
  2. Paper Details

Antiresorption therapy and reduction in fracture susceptibility in the osteoporotic elderly patient: open study.

Author: AbbateS, Lo GiudiceF, MamazzaC, MaugeriD, MuscosoE, PanebiancoP, PuglisiN, SantangeloA, TestaiM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study examined the relationship between increased bone density from anti-resorption therapies and fracture risk in 2,000 women with osteoporosis. While treatments like alendronate and risedronate increased bone density, the incidence of fractures was similar across groups. The study found that age, especially over 80, was a strong predictor of fractures, suggesting that bone density alone might not be sufficient to assess fracture risk, and that age-related changes in bone structure may be a more significant factor.
Paper Details　
Original Abstract of the Article :
The identification of risk factors for osteoporosis has been an essential step towards the understanding of the onset of the disease as well as of the osteoporosis-related fractures due to bone fragility. The present study has been aimed at assessing whether a correlation may exist between the incre...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/15267123

データ提供：米国国立医学図書館（NLM）

Bone Strength and Fracture Risk in Osteoporotic Women: A Comprehensive Study

Osteoporosis, a condition that weakens bones, is like a desert wind that erodes the foundation of our skeletal structure. This research investigated the relationship between antiresorption therapy, bone mineral density (BMD), and fracture susceptibility in a large sample of osteoporotic women. The study compared the effects of four different antiresorption therapies: alendronate, clodronate, risedronate, and raloxifene.

The Shifting Sands of Bone Health

The study found that antiresorption therapy led to an increase in BMD, particularly in those treated with alendronate or risedronate. However, the incidence of fractures remained relatively low across all treatment groups. The researchers noted that age was a significant risk factor for fractures, even in patients with increased BMD. This finding highlights the importance of considering multiple factors, beyond BMD alone, when assessing fracture risk in older individuals.

Building a Stronger Foundation

This research underscores the complex interplay between bone density, age, and fracture risk. While antiresorption therapy can help to increase bone density, it is not a foolproof solution for preventing fractures. It is crucial to consider individual risk factors, particularly age, when developing personalized treatment plans for osteoporosis.

Dr.Camel's Conclusion

This study reminds us that while antiresorption therapies can help to build stronger bones, the shifting sands of aging can still pose a significant risk for fractures. This research highlights the importance of a comprehensive approach to osteoporosis management, considering both bone density and other risk factors, particularly age. It's like a desert traveler, who must carefully consider not only the terrain but also the weather conditions to ensure a safe journey.

Date :
  1. Date Completed 2004-11-23
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

15267123

DOI: Digital Object Identifier

15267123

Related Literature

Article Analysis
・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.