[Serotonin and anticancer drug-induced emesis].

Author: EndoToru, HamaueNaoya, HirafujiMasahiko, MinamiMasaru

Paper Details 
Original Abstract of the Article :
Cytotoxic drug-induced nausea and vomiting are the side effects most feared by cancer patients. Emesis is an instinctive defense reaction caused by the somato-autonomic nerve reflex, which is integrated in the medulla oblongata. Emesis caused by anticancer drugs is associated with an increase in the...See full text at original site
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引用元:
https://doi.org/10.1248/yakushi.124.491

データ提供:米国国立医学図書館(NLM)

Serotonin's Role in Anticancer Drug-Induced Emesis

This study explores the intricate relationship between serotonin (5-HT) and anticancer drug-induced emesis, a common and often debilitating side effect of chemotherapy. The researchers, like scientists unraveling the secrets of the human body, investigated the role of 5-HT in triggering the vomiting reflex, which is often a distressing experience for cancer patients. They found that 5-HT, like a messenger carrying a signal across a vast desert, plays a crucial role in mediating the vomiting reflex. The researchers identified the enterochromaffin (EC) cells as the source of 5-HT, like a hidden oasis releasing a vital substance, and discovered that these cells stimulate the vagal afferent nerves, leading to the activation of the vomiting center in the brainstem. This research provides valuable insights into the mechanisms of anticancer drug-induced emesis, paving the way for developing more effective treatments to alleviate this distressing side effect.

Anticancer Drug-Induced Emesis: Understanding the Mechanisms

This study, like a detailed map guiding us through the complex terrain of anticancer drug-induced emesis, offers a deeper understanding of the mechanisms involved. The researchers identified 5-HT as a key player in this process, shedding light on the intricate signaling pathways that lead to the vomiting reflex. This research provides a foundation for developing more targeted treatments to alleviate the side effects of chemotherapy, improving the quality of life for cancer patients.

Chemotherapy Side Effects: Managing the Challenges

This research, like a compassionate guide offering solace in the face of a difficult journey, reminds us of the challenges faced by cancer patients undergoing chemotherapy. Understanding the mechanisms of anticancer drug-induced emesis allows healthcare providers to develop more effective strategies for managing these side effects, minimizing discomfort and improving the well-being of those battling cancer. It's like finding a cool spring of water in the heart of a scorching desert, offering relief and hope for those facing the challenges of cancer treatment.

Dr. Camel's Conclusion

This research, like a gentle breeze in the desert, offers a deeper understanding of the complex mechanisms underlying anticancer drug-induced emesis. By unraveling the role of serotonin in this process, we can develop more targeted and effective treatments to alleviate this distressing side effect, improving the quality of life for cancer patients. This research is a reminder of the incredible complexity of the human body and the power of science to unravel its mysteries, offering hope for a brighter future for those facing the challenges of cancer treatment.

Date :
  1. Date Completed 2004-09-28
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

15297719

DOI: Digital Object Identifier

10.1248/yakushi.124.491

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PICO Info
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Languages

Japanese

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