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Lack of effect of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide.

Author: BackmanJanne T, KajosaariLauri I, LaitilaJouko, NeuvonenMikko, NeuvonenPertti J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Gemfibrozil is a drug that lowers cholesterol and increases the effects of the diabetes drug repaglinide. This study will examine the effects of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide.
Paper Details　
Original Abstract of the Article :
Gemfibrozil markedly increases the plasma concentrations and blood glucose-lowering effects of repaglinide, but the effects of other fibrates on repaglinide pharmacokinetics are not known. Our aim was to investigate the effects of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynam...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884611/

データ提供：米国国立医学図書館（NLM）

The Impact of Fibrates on Repaglinide

This research is a journey through the intricate world of drug interactions, investigating the effects of bezafibrate and fenofibrate on the pharmacokinetics and pharmacodynamics of repaglinide, a medication used to manage type 2 diabetes. The study's findings reveal that while gemfibrozil significantly increases the plasma concentrations and blood glucose-lowering effects of repaglinide, bezafibrate and fenofibrate have no such impact. This research provides valuable information for healthcare professionals in understanding the potential interactions between fibrates and repaglinide, ensuring safe and effective treatment for individuals with type 2 diabetes.

The Importance of Understanding Drug Interactions

The study's findings underscore the importance of understanding drug interactions, particularly those involving medications used to manage chronic conditions. The researchers' findings highlight the need for careful consideration of potential interactions when prescribing medications, ensuring optimal therapeutic outcomes and minimizing risks for patients. This research encourages ongoing research into drug interactions, promoting safe and effective treatment strategies for individuals with various medical conditions.

Navigating the Complexities of Drug Therapy

This research is a reminder of the complexities of drug therapy and the importance of considering individual patient characteristics, including potential drug interactions. The study's findings underscore the need for comprehensive patient assessments and a thorough understanding of medication interactions to optimize therapeutic outcomes and minimize risks. This research encourages healthcare professionals to prioritize patient safety and well-being by carefully evaluating potential drug interactions before prescribing medications.

Dr.Camel's Conclusion

This research is a journey through the vast and ever-changing landscape of drug interactions, seeking to understand the complex interplay between different medications. The study's findings emphasize the importance of careful consideration of potential interactions, ensuring safe and effective treatment for individuals with type 2 diabetes. This journey through the desert of pharmacology reminds us of the need for ongoing research to enhance our understanding of drug interactions, promoting patient safety and optimal therapeutic outcomes.

Date :
  1. Date Completed 2005-01-18
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15373931

DOI: Digital Object Identifier

PMC1884611

SNS
PICO Info
in preparation
Languages

English

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