Paper Details

  1. Home
  2. Paper Details

Effects of timolol ophthalmic solution on the intra-ocular pressure rise induced by suxamethonium and tracheal intubation.

Author: BrickerS R, McGalliardJ N, MercerN P, MostafaS M, SmithG T, TrimbleR B

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Topical application of timolol ophthalmic solution 0.25% did not significantly impact responses to suxamethonium and tracheal intubation compared to normal saline in patients undergoing elective ophthalmic surgery.
Paper Details　
Original Abstract of the Article :
Thirty patients received topical application of either timolol ophthalmic solution 0.25%, or normal saline, 2 h before elective ophthalmic surgery in a double-blind study. The responses to suxamethonium and tracheal intubation were compared by measuring intra-ocular pressure before induction of anae...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1365-2044.1992.tb02021.x

データ提供：米国国立医学図書館（NLM）

Timolol and Intra-ocular Pressure

Anesthesia is a fascinating field, with its ability to temporarily alter the body's functions, like a magical desert oasis that shifts the landscape of consciousness. This study investigated the effects of timolol ophthalmic solution on intra-ocular pressure (IOP) during anesthesia. Researchers conducted a double-blind study involving 30 patients undergoing elective ophthalmic surgery. They compared the effects of timolol, a medication used to lower IOP, with normal saline. They measured IOP before and after the administration of suxamethonium, a muscle relaxant, and tracheal intubation. The study found that topical timolol did not significantly affect IOP changes induced by these procedures.

Timolol Does Not Significantly Affect IOP

The study found no significant difference in IOP between the timolol and saline groups during the procedures. This suggests that timolol, while effective in lowering IOP under normal circumstances, may not have a significant impact on IOP changes induced by suxamethonium and tracheal intubation. It's like a desert mirage, with the initial impression of a significant effect fading upon closer inspection.

Considerations for Anesthesia and IOP

The study's findings highlight the importance of considering other factors, such as the type of anesthetic used, when assessing the impact of medications on IOP. This is like understanding the interplay of different forces in the desert, such as wind and sand, to predict the effects of a sandstorm.

Dr. Camel's Conclusion

While timolol is a valuable tool for managing IOP in many cases, its effect on IOP changes during anesthesia might be less pronounced. This research sheds light on the complex interplay between medication, anesthetic procedures, and IOP. The desert of medical knowledge is vast, and we must continue to explore these interactions to develop more effective and safe treatment strategies.

Date :
  1. Date Completed 1992-04-02
  2. Date Revised 2019-07-03
Further Info :

Pubmed ID

1539791

DOI: Digital Object Identifier

10.1111/j.1365-2044.1992.tb02021.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.