The effects of acetazolamide on the ventilatory response to high altitude hypoxia.

Author: BurkiN K, HameedM A, KhanS A

Paper Details 
Original Abstract of the Article :
Acetazolamide treatment ameliorates the symptoms of AMS; however, the mechanism by which this occurs is unclear. To examine the effects of acetazolamide on oxygenation, CO2 responsiveness and ventilatory pattern during acute exposure to HA, we studied two groups of subjects at SL and following rapid...See full text at original site
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引用元:
https://doi.org/10.1378/chest.101.3.736

データ提供:米国国立医学図書館(NLM)

Acetazolamide and the Ventilatory Response to High Altitude Hypoxia

This study examines the effects of acetazolamide, a medication used to treat altitude sickness, on the ventilatory response to high altitude hypoxia. The authors investigate whether acetazolamide improves oxygenation and CO2 responsiveness during exposure to high altitude, and if it influences the pattern of breathing.

Acetazolamide and the Thin Air of High Altitude

The study found that acetazolamide treatment did not significantly alter the ventilatory pattern at high altitude. However, it was associated with better oxygenation and a higher level of ventilation compared to placebo. This suggests that the beneficial effects of acetazolamide in altitude sickness are likely due to its ability to increase ventilation and improve oxygenation, rather than affecting CO2 chemosensitivity.

Climbing the Mountain of Knowledge

This research provides valuable insights into the physiological mechanisms underlying altitude sickness and the effectiveness of acetazolamide in treating this condition. It's like climbing a challenging mountain, where understanding the effects of altitude on the body is crucial for success. This study highlights the importance of personalized approaches to managing altitude sickness, considering individual factors and potential benefits of different treatments.

Dr.Camel's Conclusion

This study provides valuable insights into the mechanisms by which acetazolamide improves oxygenation and ventilation at high altitude. It suggests that acetazolamide may be a useful treatment for altitude sickness, potentially by increasing ventilation and improving oxygen transport to the tissues. Further research is needed to understand the full range of effects of acetazolamide and to develop more effective strategies for managing altitude sickness.

Date :
  1. Date Completed 1992-04-08
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

1541140

DOI: Digital Object Identifier

10.1378/chest.101.3.736

SNS
PICO Info
in preparation
Languages

English

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