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Omeprazole (20 mg) daily given in the morning or evening: a comparison of effects on gastric acidity, and plasma gastrin and omeprazole concentration.

Author: BurgetD W, ChivertonS G, HowdenC W, HuntR H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Omeprazole is more effective when administered in the morning compared to the evening in duodenal ulcer patients. While morning administration resulted in a significant increase in mean pH, evening administration did not show a significant difference from placebo.
Paper Details　
Original Abstract of the Article :
Although omeprazole has a long duration of action and has usually been given in the morning, there are theoretical advantages in administering antisecretory drugs in the evening as has been shown for the H2-receptor antagonists. The aim of this study was to compare the effects of placebo and 20 mg o...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.1992.tb00550.x

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1992-04-10
  2. Date Revised 2019-08-27
Further Info :

Pubmed ID

1543812

DOI: Digital Object Identifier

10.1111/j.1365-2036.1992.tb00550.x

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in preparation
Languages

English

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