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Gastrointestinal side effects of intravenous erythromycin: incidence and reduction with prolonged infusion time and glycopyrrolate pretreatment.

Author: BowlerW A, HostettlerC, LavinB S, OldfieldE C, SamuelsonD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Intravenous erythromycin often causes gastrointestinal toxicity, particularly in younger patients. A 60-minute infusion with glycopyrrolate pretreatment reduced clinically important gastrointestinal toxicity by 79% compared to a 30-minute infusion with placebo.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To determine the frequency of gastrointestinal toxicity due to intravenous (IV) erythromycin and to attempt to decrease this toxicity by prolonging the infusion time of erythromycin and/or pretreating with the peripheral anticholinergic, glycopyrrolate 0.1 mg IV. DESIGN: Randomized, doub...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9343(92)90072-j

データ提供：米国国立医学図書館（NLM）

Erythromycin and the Gastrointestinal Tango

This research investigates the common side effects of intravenous erythromycin, specifically nausea and vomiting. It's like watching a tango, where the drug and the body sometimes clash in an uncomfortable rhythm. The researchers designed a carefully controlled study to explore the role of infusion time and pretreatment with glycopyrrolate in mitigating these side effects. Their findings reveal that a longer infusion time and pretreatment with glycopyrrolate significantly reduce the chances of gastrointestinal distress. The researchers also note that younger patients are more susceptible to these side effects, a finding that could be useful for guiding treatment decisions.

Infusion Time and Glycopyrrolate: A Winning Combination

The study shows that extending the infusion time of erythromycin and pre-treating with glycopyrrolate can dramatically reduce the risk of gastrointestinal toxicity. This discovery is particularly relevant for younger patients who are more prone to experiencing these side effects.

Navigating Erythromycin's Side Effects

It's crucial to remember that even with these strategies, erythromycin can still cause nausea and vomiting. It's always a good idea to discuss your concerns with your doctor and make sure you understand the potential risks and benefits of taking erythromycin.

Dr.Camel's Conclusion

This study shines a light on the importance of personalized medicine, where factors like age and individual responses to drugs are taken into account. It's like navigating a vast desert, where the journey may be different for each traveler. By adjusting the route and taking precautions, we can avoid the harsh side effects of erythromycin and ensure a smoother, healthier journey.

Date :
  1. Date Completed 1992-04-10
  2. Date Revised 2019-06-26
Further Info :

Pubmed ID

1546723

DOI: Digital Object Identifier

10.1016/0002-9343(92)90072-j

SNS
PICO Info
in preparation
Languages

English

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