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[Efficacy and acceptability of the fixed fluticasone + salmeterol combination in the treatment of acute asthma attacks. Results of a one-year comparative study].

Author: DesfougèresJ-L, TonnelA-B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The fixed fluticasone/salmeterol combination provided a protection equivalent to that obtained with free combinations over a one-year treatment period for asthma. It also showed a significant improvement in treatment acceptability.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The objective of an asthma treatment is to control asthma, particularly to prevent exacerbations. OBJECTIVE: To study the efficacy, acceptability and safety of the fluticasone/salmeterol (FP/S) combination in preventing asthma exacerbations in comparison with the continuation of previou...See full text at original site
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引用元：
https://doi.org/10.1016/s0761-8417(04)72101-x

データ提供：米国国立医学図書館（NLM）

Fluticasone + Salmeterol: A Fixed Combination for Acute Asthma Attacks

Asthma, a chronic inflammatory lung disease characterized by airway narrowing and breathing difficulties, can significantly impact an individual's quality of life. This study, a journey through the desert of asthma management, investigates the efficacy, acceptability, and safety of a fixed combination of fluticasone and salmeterol in preventing asthma exacerbations.

A Comparative Study: Evaluating a Fixed Combination

Researchers conducted a randomized, parallel-group study involving 520 patients with well-controlled asthma. Participants were randomly assigned to receive either the fixed combination of fluticasone/salmeterol or a free combination of an inhaled corticosteroid and a long-acting beta2-agonist. This study, like a carefully controlled experiment in a desert research laboratory, sought to compare the effectiveness of different treatment strategies for preventing asthma exacerbations.

The Results: A Comparable and Acceptable Option

The findings revealed that the fixed combination of fluticasone/salmeterol was at least as effective as the free combination in preventing asthma exacerbations. Moreover, the fixed combination was found to be more acceptable to patients, demonstrating its ease of use and integration into daily routines.

Health Implications and Everyday Life: Breathing Easier in the Desert

This research, a beacon of hope in the desert of asthma management, demonstrates the efficacy, acceptability, and safety of the fixed combination of fluticasone/salmeterol in preventing asthma exacerbations. For individuals with asthma, this research offers a potential for better control of their condition through a convenient and well-tolerated treatment option.

Dr. Camel's Conclusion

This research, a valuable exploration in the desert of asthma management, highlights the efficacy, acceptability, and safety of a fixed combination of fluticasone/salmeterol. The findings suggest that this fixed combination may offer a valuable alternative to free combinations, providing a more convenient and well-tolerated approach to asthma management.

Date :
  1. Date Completed 2005-05-17
  2. Date Revised 2019-11-09
Further Info :

Pubmed ID

15545949

DOI: Digital Object Identifier

10.1016/s0761-8417(04)72101-x

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・Effective treatment of asthma
SNS
PICO Info
in preparation
Languages

French

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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