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Neuraminidase inhibitor-rimantadine combinations exert additive and synergistic anti-influenza virus effects in MDCK cells.

Author: FangHong-Bin, GovorkovaElena A, TanMing, WebsterRobert G

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the effects of combining neuraminidase (NA) inhibitors (zanamivir, oseltamivir carboxylate, or peramivir) with rimantadine against influenza A virus infection. The combination showed additive and synergistic effects in reducing extracellular virus, with no cytotoxicity. However, effects on cell-associated virus yield were more complex, suggesting that different methods of analysis can influence the evaluation of drug combinations. Overall, these findings suggest that combining NA inhibitors with rimantadine could be a promising strategy for treating influenza infections.
Paper Details　
Original Abstract of the Article :
There is insufficient information about combination therapy with approved anti-influenza agents. We tested combinations that paired a neuraminidase (NA) inhibitor (zanamivir, oseltamivir carboxylate, or peramivir) with rimantadine against infection of MDCK cells with H1N1 and H3N2 subtypes of influe...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC529183/

データ提供：米国国立医学図書館（NLM）

Fighting the Flu: A Two-Pronged Attack

The influenza virus, a notorious seasonal foe, can wreak havoc on our immune systems. This study investigates the potential benefits of combining two different types of anti-influenza drugs: neuraminidase inhibitors (NAIs) and rimantadine. The research delved into the synergistic effects of these drugs against both H1N1 and H3N2 subtypes of influenza A virus in laboratory cell cultures. The researchers found that these combinations showed additive and synergistic effects, meaning they worked better together than individually, potentially offering a more effective treatment strategy for influenza.

A Powerful Partnership Against the Flu

This research suggests that combining NAIs and rimantadine could be a potent weapon against influenza. The study found that this combination exhibited synergistic effects in reducing the amount of virus in cell cultures. This suggests that pairing these drugs could lead to a more effective treatment strategy for influenza, potentially reducing the duration and severity of infection. However, further research is needed to validate these findings in humans.

Staying Ahead of the Flu: A Proactive Approach

As we navigate the desert landscape of flu season, it's important to remember that a proactive approach to health is key. Getting vaccinated annually, maintaining good hygiene practices, and staying informed about the latest flu developments can all help in minimizing the risk of infection. In the event of an influenza infection, seeking medical advice and following prescribed treatments are crucial for a speedy recovery.

Dr.Camel's Conclusion

This study presents a compelling case for exploring combination therapies in fighting the flu. The potential synergistic effects of NAIs and rimantadine offer hope for more effective treatment options. It's a reminder that in the face of infectious diseases, we can learn a lot from the collaborative nature of the desert ecosystem, where different species work together to thrive.

Date :
  1. Date Completed 2005-01-18
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15561867

DOI: Digital Object Identifier

PMC529183

Related Literature

Article Analysis
・Effects of rimantadine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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