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Sucralfate and ranitidine twice daily in the treatment of gastric ulcer. A multicenter randomized double-blind study.

Author: ArchimandritisA, CharitopoulosN, DiamantisT, KitisG, KokozidisG, MallasE, TjivrasM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Sucralfate and ranitidine were equally effective in the short-term treatment of gastric ulcers. Both drugs achieved similar healing rates at 4 and 8 weeks.
Paper Details　
Original Abstract of the Article :
Sucralfate and ranitidine were compared in the treatment of gastric ulcer (GU) in this multicenter randomized double-blind study. Sixty-four patients with endoscopically diagnosed GU initially included in the trial were randomly assigned to treatment with sucralfate, 2 g b.i.d. (morning and evening ...See full text at original site
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引用元：
https://doi.org/10.1097/00004836-199201000-00003

データ提供：米国国立医学図書館（NLM）

Sucralfate vs. Ranitidine: A Tale of Two Ulcer Treatments

This research explores the effectiveness of two medications - sucralfate and ranitidine - in treating gastric ulcers. The researchers conducted a multicenter, randomized, double-blind study involving 64 patients with endoscopically diagnosed gastric ulcers. They randomly assigned patients to receive either sucralfate or ranitidine twice daily. The study found no significant difference in the healing rates between the two medications at both 4 and 8 weeks. Furthermore, there were no differences in healing effects between smokers and non-smokers, nor were there significant differences in side effects.

Ulcer Treatment: A Choice Between Two Effective Options

The findings suggest that both sucralfate and ranitidine are equally effective in the short-term treatment of gastric ulcers. The study's robust design, utilizing a randomized, double-blind approach, enhances the reliability of its conclusions. This research provides valuable information for healthcare professionals and patients seeking effective treatments for gastric ulcers.

Navigating the Sands of Ulcer Treatment: A Balanced Approach

This research reminds us that there are often multiple effective options for managing medical conditions. It encourages a balanced approach to treatment, considering factors like individual preferences, potential side effects, and cost-effectiveness. It's essential to consult with your healthcare provider to determine the best treatment plan for your specific needs.

Dr.Camel's Conclusion

This research is like a desert oasis, providing a choice of refreshing treatments for gastric ulcers. Sucralfate and ranitidine emerge as equally effective options, allowing patients to choose the best path for their individual needs. Remember, just as a desert traveler must be discerning about water sources, so should we be about medication choices. Consult your doctor to find the best treatment for your health.

Date :
  1. Date Completed 1992-05-04
  2. Date Revised 2019-08-17
Further Info :

Pubmed ID

1556414

DOI: Digital Object Identifier

10.1097/00004836-199201000-00003

Related Literature

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・Side Effects of sucralfate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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