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Effect of Mycobacterium vaccae (SRL172) immunotherapy on radiographic healing in tuberculosis.

Author: ChintuC, FourieP B, JohnsonJ L, MugerwaR D, MwingaA, NgwiraB, NunnA J, OnyebujohP, OrmerodL P, ZumlaA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Adjunctive immunotherapy of drug-susceptible pulmonary tuberculosis (TB) with Mycobacterium vaccae during the first 2 weeks of treatment did not improve radiographic responses to treatment or resolution of cavitary disease.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Controlled trials have failed to show an effect of Mycobacterium vaccae immunotherapy on treatment outcome and mortality in patients with tuberculosis (TB); however, several studies have suggested improvement in radiographic clearing and resolution of cavitary disease. METHODS: To assess...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15581204

データ提供：米国国立医学図書館（NLM）

Mycobacterium vaccae Immunotherapy: Not a Game Changer for Tuberculosis

Tuberculosis (TB), a persistent global health threat, continues to be a challenge for researchers and clinicians. This research investigates the potential of Mycobacterium vaccae immunotherapy as an adjunct treatment for pulmonary TB. The authors analyzed data from three randomized placebo-controlled trials, assessing the impact of M. vaccae immunotherapy on radiographic healing in TB patients. Their findings suggest that M. vaccae immunotherapy, while showing promise in some studies, did not demonstrate a significant improvement in radiographic healing outcomes compared to placebo.

Mycobacterium vaccae Immunotherapy: A Limited Role in TB Treatment?

The study's findings cast doubt on the effectiveness of M. vaccae immunotherapy as an adjunct treatment for pulmonary TB. While some previous studies suggested potential benefits in radiographic healing, the results of these three randomized controlled trials do not support this claim. The authors' findings emphasize the need for further research to explore the potential role of M. vaccae in TB treatment, potentially identifying specific subgroups of patients who might benefit from this approach.

Navigating the Challenges of TB Treatment: A Search for Effective Therapies

TB treatment remains a complex challenge, requiring a multi-faceted approach that includes effective drug regimens and potentially novel therapies. This research contributes to the ongoing evaluation of potential adjunct therapies for TB, highlighting the importance of rigorous clinical trials to assess the true efficacy of promising treatments. The search for effective therapies to combat TB continues, with ongoing research exploring new strategies to improve patient outcomes and reduce the global burden of this disease.

Dr.Camel's Conclusion

Tuberculosis, a disease that has plagued humanity for centuries, remains a formidable foe. This research, while not finding a clear benefit for M. vaccae immunotherapy, reminds us that the fight against TB requires ongoing investigation and innovation. The quest for better treatments continues, with researchers exploring new avenues to combat this persistent global health challenge.

Date :
  1. Date Completed 2014-06-26
  2. Date Revised 2019-01-01
Further Info :

Pubmed ID

15581204

DOI: Digital Object Identifier

15581204

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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