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Effect of bupropion on depression symptoms in a smoking cessation clinical trial.

Author: Audrain-McGovernJanet, CollinsBradley N, EpsteinLeonard H, HawkLarry, LermanCaryn, NiauraRay, PintoAngela, WileytoPaul

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Bupropion is effective for helping smokers quit, but it can increase depression symptoms in highly nicotine-dependent smokers. This study found that bupropion can reduce depression symptoms during treatment but that these symptoms may return when the drug is stopped.
Paper Details　
Original Abstract of the Article :
Bupropion is an antidepressant shown to be efficacious for smoking cessation. This study examined the short- and long-term effects of bupropion (300 mg/day for 10 weeks) versus placebo on depression symptoms among 497 smokers attempting to quit in a randomized trial of bupropion plus behavioral coun...See full text at original site
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引用元：
https://doi.org/10.1037/0893-164X.18.4.362

データ提供：米国国立医学図書館（NLM）

Bupropion: A Desert Oasis for Smokers with Depression

Quitting smoking is a tough journey, like traversing a scorching desert. For those struggling with depression, the journey can be even more challenging. This study explored the effects of bupropion, a medication often used for both smoking cessation and depression, on smokers attempting to quit.

The Unexpected Oasis: Bupropion's Double Benefit

Researchers found that highly nicotine-dependent smokers who took bupropion experienced a decrease in depression symptoms during active treatment. This suggests that bupropion may provide a double benefit, aiding in both smoking cessation and managing depression. However, the researchers also observed a rebound in depression symptoms when bupropion was discontinued, highlighting the need for careful management during this transition period.

Navigating the Shifting Sands of Depression

This research offers a valuable insight into the complex relationship between nicotine dependence, depression, and smoking cessation. While bupropion can be a helpful tool, it's important to be aware of the potential for rebound depression and work closely with your doctor to manage your mental health during the quitting process. Just as a desert traveler needs to plan for the changing landscape, smokers with depression need to be prepared for potential challenges and seek guidance.

Dr.Camel's Conclusion

This research offers a valuable perspective on the impact of bupropion on depression in smokers. While it shows potential benefits, it also highlights the need for careful monitoring and management of depression symptoms. Like a desert traveler, it's crucial to have a plan in place to navigate any potential challenges and seek support when needed.
Date :
  1. Date Completed 2005-09-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15631608

DOI: Digital Object Identifier

10.1037/0893-164X.18.4.362

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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