Chemoradiotherapy for primary CNS lymphoma: an intent-to-treat analysis with complete follow-up.

Author: AbreyLauren E, DeAngelisLisa M, OmuroAntonio M P, YahalomJoachim

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To assess the efficacy and safety of a preradiation chemotherapy regimen in patients with primary CNS lymphoma (PCNSL), with emphasis on long-term outcomes. METHODS: In this prospective phase II trial, patients with a new diagnosis of PCNSL received two cycles of intrathecal (12 mg) and ...See full text at original site
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引用元:
https://doi.org/10.1212/01.WNL.0000148641.98241.5E

データ提供:米国国立医学図書館(NLM)

Combating Primary CNS Lymphoma: A Multimodal Approach

Dr. Camel here, ready to explore the world of primary central nervous system lymphoma (PCNSL), a challenging type of cancer that affects the brain and spinal cord. This research examines the efficacy and safety of a multimodal treatment regimen combining chemotherapy and radiation therapy for PCNSL. It's like a desert expedition, employing a multi-pronged approach to battle a formidable foe.

A Combined Strategy

The study explores the effectiveness of a preradiation chemotherapy regimen followed by whole-brain radiotherapy. It's a combined effort, like a caravan of camels working together to overcome obstacles in a harsh desert. The research reveals promising results, showing a high rate of complete response after treatment, demonstrating the potential of this multimodal approach to effectively combat PCNSL.

Challenges and Long-Term Outcomes

While the study highlights the effectiveness of this treatment regimen, it also acknowledges the challenges associated with long-term outcomes. The research emphasizes the importance of continued monitoring and follow-up to address potential relapses. It's a continuous journey through the desert of cancer treatment, requiring vigilance and ongoing care. The study also underscores the need for research into strategies to minimize neurotoxicity, a common side effect of treatment. It's a quest for more effective and safer treatments, like seeking a hidden oasis of hope in a vast desert.

Dr. Camel's Conclusion

This research offers a valuable contribution to the field of PCNSL treatment, highlighting the potential of a multimodal approach combining chemotherapy and radiation therapy. It's a testament to the ongoing quest for better treatments for this challenging disease, reminding us that the journey through the desert of cancer research is a continuous one, requiring persistent exploration and innovation to find more effective and safer solutions.

Date :
  1. Date Completed 2005-09-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15642906

DOI: Digital Object Identifier

10.1212/01.WNL.0000148641.98241.5E

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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