Brivudin compared with famciclovir in the treatment of herpes zoster: effects in acute disease and chronic pain in immunocompetent patients. A randomized, double-blind, multinational study.

Author: , WassilewSw

Paper Details 
Original Abstract of the Article :
OBJECTIVE: This was a double-blind, randomized multicentre trial comparing efficacy and safety of brivudin (125 mg, once a day) and famciclovir (250 mg, three times a day), both given orally for 7 days, in the treatment of herpes zoster. METHODS: A total of 2027 immunocompetent zoster patients>or=5...See full text at original site
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引用元:
https://doi.org/10.1111/j.1468-3083.2004.01119.x

データ提供:米国国立医学図書館(NLM)

Brivudin vs. Famciclovir for Herpes Zoster: A Comparative Analysis of Efficacy and Safety

Herpes zoster, commonly known as shingles, is a viral infection that can cause painful skin rashes and potentially lead to long-term complications. This randomized, double-blind, multinational study compares the efficacy and safety of two antiviral medications, brivudin and famciclovir, for the treatment of herpes zoster in immunocompetent patients. The researchers found that both medications were equally effective in reducing the prevalence of postherpetic neuralgia (PHN), a painful condition that can persist after the initial rash. The study also found that both drugs were well-tolerated, with similar side effect profiles. While brivudin offered equivalent efficacy at a more convenient once-daily dosing schedule, the study highlights the importance of early diagnosis and treatment to minimize the risk of developing PHN.

Fighting Shingles: A Comparative Look at Antiviral Medications

The study provides valuable insights into the treatment of herpes zoster, comparing the efficacy and safety of two commonly used antiviral medications, brivudin and famciclovir. The findings suggest that both medications are effective in reducing the risk of developing PHN, a painful complication that can persist after the initial rash. The study emphasizes the importance of early diagnosis and prompt treatment to minimize the risk of developing PHN, underscoring the need for effective antiviral therapies for managing herpes zoster.

Navigating the Desert of Pain: A Guide to Managing Herpes Zoster

Imagine traversing a vast desert, where the scorching sun and unforgiving terrain pose constant challenges. This analogy reflects the experience of individuals suffering from herpes zoster, where the pain can be unrelenting and debilitating. This study offers valuable insights into the treatment options for herpes zoster, guiding us towards effective therapies that can mitigate the pain and prevent long-term complications.

Dr.Camel's Conclusion

This study provides valuable insights into the comparative efficacy and safety of brivudin and famciclovir for the treatment of herpes zoster. The findings highlight the importance of early diagnosis and prompt treatment with antiviral medications to minimize the risk of developing postherpetic neuralgia, a painful complication that can persist after the initial rash.

Date :
  1. Date Completed 2005-06-01
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

15649191

DOI: Digital Object Identifier

10.1111/j.1468-3083.2004.01119.x

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SNS
PICO Info
in preparation
Languages

English

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