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Once daily cefixime compared with twice daily trimethoprim/sulfamethoxazole for treatment of urinary tract infection in infants and children.

Author: DaganR, EinhornM, LangR, MironD, PomeranzA, RazR, SteinbergerJ, WeinstockA, WeintraubA, WolachB

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cefixime administered once daily was as safe and effective as TMP/SMX administered twice daily in treating acute uncomplicated urinary tract infection in children. Both groups had similar recovery rates and side effects were mild.
Paper Details　
Original Abstract of the Article :
We conducted a randomized prospective multicenter study to compare the safety and efficacy of once daily oral cefixime (8 mg/kg) to twice daily oral trimethoprim/sulfamethoxazole (TMP/SMX) (8/40 mg/kg/day) for the treatment of acute urinary tract infection in children ages 6 months to 13 years. Seve...See full text at original site
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引用元：
https://doi.org/10.1097/00006454-199203000-00005

データ提供：米国国立医学図書館（NLM）

Cefixime vs. Trimethoprim/Sulfamethoxazole: A Head-to-Head Comparison

Urinary tract infections (UTIs) are common in children, and finding effective and safe treatment options is crucial. This study compared the safety and efficacy of cefixime, a once-daily oral antibiotic, with trimethoprim/sulfamethoxazole (TMP/SMX), a twice-daily oral antibiotic, for treating UTIs in children.

Seventy-six children (38 in each group) aged 6 months to 13 years were enrolled in the study. Both groups received treatment for 7 to 10 days. The study found that both cefixime and TMP/SMX were effective and safe in treating UTIs in children. Both groups showed similar improvements in white blood cell counts, erythrocyte sedimentation rate, body temperature, and urinalysis results.

Cefixime: A Potential Alternative

The study highlights the potential of cefixime as a convenient and effective treatment option for uncomplicated UTIs in children. This antibiotic, administered once daily, provides comparable efficacy and safety to TMP/SMX, which requires twice-daily administration.

Key Considerations for UTI Management

Finding the right treatment for UTI is like finding the right path in a vast desert. This study suggests that cefixime might be a valuable tool in managing UTIs in children. However, it's essential to consult a doctor for diagnosis and to receive the appropriate treatment, especially for infants and young children.

Dr.Camel's Conclusion

This study is like a refreshing spring in the desert, offering a new option for treating UTIs in children. Cefixime provides a convenient alternative to TMP/SMX, easing the burden of frequent medication administration.

Date :
  1. Date Completed 1992-05-21
  2. Date Revised 2019-08-18
Further Info :

Pubmed ID

1565534

DOI: Digital Object Identifier

10.1097/00006454-199203000-00005

Related Literature

Article Analysis
・Side Effects of cefixime
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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