Validation of the tremulous jaw movement model for assessment of the motor effects of typical and atypical antipychotics: effects of pimozide (Orap) in rats.

Author: BetzAdrienne, FelstedJennifer, IshiwariKeita, SalamoneJohn D, WeberSuzanne

Paper Details 
Original Abstract of the Article :
Drug-induced tremulous jaw movements (TJMs) in rats have been used as a model of parkinsonian tremor. Previous studies demonstrated that the typical antipsychotic haloperidol induced TJMs after acute or subchronic administration, while atypical antipsychotics did not. Moreover, it has been suggested...See full text at original site
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引用元:
https://doi.org/10.1016/j.pbb.2004.12.006

データ提供:米国国立医学図書館(NLM)

Tremulous Jaw Movements: A Window into Antipsychotic Effects

Antipsychotic medications are often used to manage mental health conditions, but these drugs can sometimes have unintended side effects. This research explores the use of a rat model to study the motor effects of antipsychotics, specifically focusing on drug-induced tremulous jaw movements (TJMs). The authors aim to validate this model as a tool to distinguish between typical and atypical antipsychotics.

TJMs: A Unique Model for Antipsychotic Evaluation

This study reveals that TJMs can serve as a valuable model to assess the motor effects of antipsychotics, particularly in distinguishing between typical and atypical drugs. Think of it as a desert explorer using a unique compass to navigate the complex terrain of antipsychotic effects. The researchers found that typical antipsychotics, such as pimozide, induced TJMs in rats, while atypical antipsychotics did not.

Navigating the Side Effects of Antipsychotics

This research underscores the importance of understanding the potential side effects of antipsychotic medications. It's crucial to work closely with your healthcare provider to monitor for any signs of motor disturbances, like a desert traveler carefully observing their surroundings for potential dangers. By staying vigilant and working together, we can ensure the safety and well-being of individuals taking these medications.

Dr. Camel's Conclusion

This study offers a unique glimpse into the complex world of antipsychotic medications, showcasing the importance of careful monitoring and understanding potential side effects. By studying TJMs in rats, we can better navigate the terrain of antipsychotic effects, ensuring the safety and well-being of those seeking relief from mental health conditions.

Date :
  1. Date Completed 2005-06-24
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

15680188

DOI: Digital Object Identifier

10.1016/j.pbb.2004.12.006

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